Thiothixene

DEA Class;  Rx

Common Brand Names; Navane

Documented hypersensitivity

Blood dyscrasias

Coma

Circulatory collapse

CNS depression (including coma)

• Constipation
• Decr sweating
• Drowsiness
• EPS ( muscle stiffness, dystonia, Parkinsonism, tardive dyskinesia, akathisia) (60%)
• Incr appetite
• Orthostatic hypotension
• Photosensitivity
• Wt gain
• Xerostomia
• Agitation
• Allergic dermatitis
• Allergic reactions
• Anorexia
• Anticholinergic effects
• Anxiety
• Cerebral edema
• Depression
• Dizziness
• Erectile dysfunction
• Euphoria
• Headache
• Ileus
• Insomnia
• Irregular menses
• Lens opacities (prolonged use)
• Poikilothermia
• Rash
• Restlessness
• Sedation
• Tachycardia
• Weakness
• Agranulocytosis, blood dyscrasias (rare)
• Galactorrhea (rare)
• Heat stroke (rare)
• NMS (infrequent but serious)
• Obstructive hyperbilirubinemia (rare)
• Cholestatic jaundice
• Confusion
• Decr gag reflex
• Gynecomastia
• Hyperpyrexia
• Peripheral edema

Potential cross-sensitivity between thioxanthenes & phenothiazine derivative

Not for use for dementia in elderly

Antiemetic effect observed in animal studies; since this effect may also occur in man, it is possible that this drug may mask signs of overdosage of toxic drugs and may obscure conditions such as intestinal obstruction and brain tumor

Consider known capability of this drug and certain other psychotropic drugs to precipitate convulsions, use extreme caution in patients with history of convulsive disorders or those in a state of alcohol withdrawal; it may lower convulsive threshold; although this drug potentiates the actions of the barbiturates, the dosage of the anticonvulsant therapy should not be reduced when this drug is administered concurrently

Exhibits rather weak anticholinergic properties; use with caution in patients who might be exposed to extreme heat or who are receiving atropine or related drugs

Use with caution in patients with cardiovascular disease

Use caution and adjust dose when used in conjunction with other CNS depressants

Carefully observe for pigmentary retinopathy and lenticular pigmentation (fine lenticular pigmentation has been noted in a small number of patients treated with this drug for prolonged periods); blood dyscrasias (agranulocytosis, pancytopenia, thrombocytopenic purpura), and liver damage (jaundice, biliary stasis) reported with related drugs

Safe use during pregnancy not established; drug should be given to pregnant patients only when, in the judgment of the physician, the expected benefits from treatment exceed possible risks to mother and fetus

Not known if drug excreted in breast milk; other agents preferred in nursing mothers