This KAPS Quiz contains older questions to help you practise. These questions are no longer used, but they’ll help you understand:
- the types of content covered in each paper of the exam
- how questions might be presented
If you want to practise the sample papers under exam conditions, you’ll need to answer all 100 questions in each paper in 2 hours.
Paper 1 | Pharmaceutical chemistry 50% Pharmacology and physiology 50% |
Paper 2 | Pharmaceutics 50% Therapeutics 50% |
Here is the Test 2 Paper 2
Section 1 = 30 Questions
Section 2 = 70 Questions
Section 1
The elimination half-life of penicillin G is approximately 0.5 hours. Thus when administered IV every six hours
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Which ONE of the following insulin preparations has a duration of action of less than 12 hours?
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After initial immunisation with tetanus toxoid, booster injections should be given every
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The Rideal-Walker test is used to measure the
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Fluphenazine dodecanoate is administered:
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In some situations there may NOT be an obvious relationship between the intensity of the pharmacological response of a drug and the plasma concentration of that drug because:
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Which ONE of the following statements is INCORRECT? Sublingual drug administration is suitable for drugs that:
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What is meant by the term "steady state" in relation to the plasma levels of a drug?
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Which ONE of the following suppository bases is immiscible with body fluids?
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Given that: (i) ascorbic acid (Vitamin C), in an aqueous mixture decomposes by first order kinetics and (ii) the half-life of ascorbic acid in this mixture at shelf temperature is 8 months, What is the acceptable shelf-life of ascorbic acid in aqueous solution assuming that it is unacceptable when its initial concentration is reduced by 1/8?
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Which ONE of the following statements about capsules is NOT true?
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A suitable method for the sterilisation of a solution of a thermolabile drug for ophthalmic use is
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A drug active against methicillin-resistant staphylococcal strain is:
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Stearyl alcohol, cetyl alcohol, cholesterol and other related compounds are used as
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Cocaine has two ester bonds that hydrolyse to produce either benzoylecgonine or ecgonine methyl ester. At 40 °C and pH 7.25, cocaine has a half-life of 5 h. If the total extent of degradation is not allowed to be more than 10% what would the shelf-life be for cocaine under those conditions?
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Certain tablets contain micronised drug particles because
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Surface-active agents are included in some tablets to
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Morphine in a 70 kg patient taking 20 mg sustained-release capsules twice daily was found to have a steady-state concentration of 4 ng/mL. Assuming a bioavailability of 25%, the clearance of morphine from this patient was
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Particle size and crystal structure are generally important factors in bioavailability from oral dosage forms when:
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A prescription calls for 0.1% chlorhexidine hydrochloride in an oil-in-water emulsion cream base. Which ONE of the following is the MOST suitable emulgent for the preparation of the base?
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Total parenteral nutrition fluids should be stored
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Chalk 1.5 g Light kaolin 2.5 g Alum 10 mg Concentrated chloroform water 0.25 mL Purified water 10 mL The inclusion of the alum in the above formulation is to
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Dosage adjustment in patients with renal impairment can be based on:
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Which of the following drugs is NOT used sublingually?
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Psyllium is MOST likely to be used to manage the side effect of which medication?
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A soap can be formed by a reaction between:
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Sodium polystyrene sulfonate achieves its therapeutic effect by acting as an exchange resin. Which ONE of the following ions is exchanged with sodium?
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The elimination half-life for ranitidine is approximately 2 hours. What percentage of this drug would be eliminated from the body 4 hours after an intravenous (IV) bolus dose?
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The antiarrythmic agent, lignocaine, is unsuitable for oral administration because it:
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Chlorocresol is used as a preservative in oil-in-water creams at a percentage concentration of
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 2 Paper 2 Section 1
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%
FAIL
Results
Paper 2 Section 1 Pharmaceutics Passing Score 50%
Pass
Section 2
The usual starting dose for venlafaxine is
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The most common side effect(s) associated with ketoconazole is/are
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All of the following statements apply when considering oestradiol nasal spray EXCEPT:
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In the management of gout, all of the following statements are correct EXCEPT:
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Which ONE of the following represents the highest concentration?
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Toxic effects of the tricyclic antidepressants include all of the following EXCEPT:
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The maximum recommended dose of acarbose is:
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Paraffin is what type of laxative?
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A woman brings the following prescription to the pharmacy after visiting the oncologist: Sucralfate 1 g 8 tablets Sorbitol 70% 40 mL Water qs ad 120 mL Sig: swish and expectorate 10 mL q 4h How much sucralfate is in 10 mL of this product?
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All of the following statements regarding black cohosh are true EXCEPT:
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Over the counter aspirin-containing preparations are generally not recommended for children under the age of 16 years because of the risk of
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Patients given monoamine oxidase inhibitors (MAOI) should avoid matured cheese in their diet because substances are present in cheese that:
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Clinically significant drug interactions occur between warfarin and
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Which ONE of the following is NOT an osmotic laxative?
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What needle size has the smallest diameter?
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Which ONE of the following statements about alcoholic and aqueous echinacea extracts does NOT apply? They:
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The anthracycline group of antineoplastic drugs (eg doxorubicin, epirubicin, daunorubicin) are associated with which ONE of the following groups of adverse effects?
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Which of the following is a potential common problem with the use of fluoxetine?
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When determining the appropriate dosage of frusemide for an individual patient, it is most appropriate to consider
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Which of the following is TRUE?
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Which treatment course with gentamicin is more likely to cause nephrotoxicity?
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SULFACETAMIDE EYE-DROPS Sulphacetamide sodium 10 g Sodium metabisulphite 0.1 g Disodium edetate 0.05 g Phenylmercuric nitrate 0.002 g Water for injections to 100 mL The phenylmercuric nitrate is available as a sterile aqueous solution containing 3 mg in 10 mL. The volume of this solution required to prepare 15 mL of the above formula is:
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Clotrimazole is available in pessary form to treat vaginal candidiasis. The correct dose is:
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Which ONE of the following drugs may induce thyrotoxicosis?
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Moclobemide is a reversible inhibitor of the enzyme monoamine oxidase. The frequency and severity of food and drug interactions with the traditional irreversible monoamine oxidase inhibitors is significantly reduced with this drug. However, moclobemide should NEVER be prescribed in combination with:
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If a patient has been ordered salbutamol aerosol and beclomethasone aerosol, both to be inhaled four times a day, the patient should inhale the beclomethasone:
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Which ONE of the following drugs would NOT increase serum theophylline levels?
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Pharmacological strategies used to treat drug addiction include
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Rachel, a female customer, has a prescription for aciclovir for shingles (which started 2 days ago). She is uncertain about filling it due to the cost. Based on the known effectiveness for herpes zoster, which ONE of the following should the pharmacist discuss with Rachel? Aciclovir
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Which one of the following combinations of drugs has been shown to prolong the QT interval?
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Which ONE of the following suggested doses would NOT be appropriate for an adult?
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A solution with a concentration of 0.05 per cent may also be described as containing
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Which of the following statements is NOT true? Aspirin
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Following initial successful use of aerosol bronchodilators, a subsequent increase in requirement may be due to any of the following EXCEPT:
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How much of a 10% injection of a drug is required to make 100 mL of a mixture containing 7.5 mg in 2.5 mL?
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The MOST common adverse effect of raloxifene is
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A common side effect of minocycline is
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Which ONE of the following is a recommended treatment option for severe pain due to acute herpes zoster?
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Which of the following statements is NOT true regarding the management of drug therapy in the elderly?
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Which ONE of the following drugs does NOT have a place in the acute treatment of migraine?
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A patient receiving tranylcypromine should avoid:
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Which ONE of the following drugs is used to treat vertigo?
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Drug-induced agranulocytosis refers to
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All of the following agents represent an approved OTC treatment for acne vulgaris EXCEPT:
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Which ONE of the following drugs may be administered to a patient with a known sulfonamide allergy?
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A woman has a prescription for 32 mmol/day KCl orally. The pharmacy has 600 mg KCl controlled-release tablets. How many tablets does she need to take each day to provide this dose? [Mol Wt KCl: 74.5]
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The normal sublingual dose of glyceryl trinitrate is within the range of
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After surgery, (radical thyroidectomy), what dose of thyroxine would you recommend therapy be initiated on?
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Norethisterone is used to treat a variety of conditions. Which of the following doses is INCORRECT?
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At what age should an infant be immunised against measles?
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A patient stabilised on lithium has been diagnosed with mild hypertension. Non-drug intervention has been recommended. Which ONE of the following may cause an elevation of lithium plasma levels with a resultant risk of toxicity?
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A patient who presents while on cephalosporins with fever, malaise and blistering of the skin is likely to have:
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A pharmacist is required to produce a litre of a sodium chloride solution of such a strength that when 20 mL is diluted to 100mL with water, the resulting concentration will be 0.9% w/v. The only available sodium chloride is in the form of tablets each containing 2.25 g. The number of tablets required is
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Which ONE of the following antimicrobials is considered safe in pregnant women?
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A thiazide diuretic can
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Absorption of a bile acid-binding resin:
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Which of the following effects are LEAST likely to occur with L-DOPA?
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Which ONE of the following drugs may be used intravenously to treat closed angle glaucoma?
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Sulfonamides are antagonised by:
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What advice would you give to a patient prescribed benzoyl peroxide gel for acne?
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Which type of laxative includes the agent docusate sodium?
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What advice would you NOT give to a patient prescribed rifampicin capsules for long term treatment?
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Once opened, the correct shelf life of an appropriately stored bottle of glyceryl trinitrate (GTN) 600 microgram tablets is:
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For a weak base, according to the Henderson-Hasselbalch equation: When the pKa of a base is equal to 9 and the ratio of the non- ionised species to the ionised species is 10:1, the pH equals
1
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Tricyclic antidepressants do NOT interfere with the antihypertensive action of:
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Which ONE of the following would NOT be a factor in determining the therapeutic approach to Ms Slocum's breast cancer?
1
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In choosing a chemotherapy regimen for Ms Slocum, the doctor should consider all of the following factors EXCEPT:
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Which ONE of the following diagnostic tests would be MOST appropriate to determine if Ms Slocum is a candidate for endocrine therapy?
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Ms Slocum complains about frequent hot flushes. This is associated with:
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The medication prescribed for Ms Slocum on September 10 acts as:
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 2 Paper 2 Section 2
Result
Paper 2 Section 1 Paper 2 Section 2 Pharmaceutics Passing Score 50%
Fail
Result
Paper 2 Section 1 Paper 2 Section 2 Pharmaceutics Passing Score 50%
Pass