This KAPS Quiz contains older questions to help you practise. These questions are no longer used, but they’ll help you understand:
- the types of content covered in each paper of the exam
- how questions might be presented
If you want to practise the sample papers under exam conditions, you’ll need to answer all 100 questions in each paper in 2 hours.
Paper 1 | Pharmaceutical chemistry 50% Pharmacology and physiology 50% |
Paper 2 | Pharmaceutics 50% Therapeutics 50% |
Here is the Test 1 Paper 2
Section 1 = 30 Questions
Section 2 = 70 Questions
Section 1
Small changes in dose may lead to disproportionate increases in blood levels of
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If a fixed dose of a drug that is eliminated by first order kinetics is administered intravenously at regular intervals, the time required to achieve a steady state plasma level depends only on the
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A basic principle of drug absorption is that a drug is usually NOT absorbed
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The system which is composed of a liquid dispersed in a liquid is
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Which of the following characteristics is CORRECT for cationic aqueous creams?
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Which of the following drugs is NOT absorbed systemically when given by mouth?
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Occlusive dressings are used clinically with topical corticosteroids to
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If a drug has a very small volume of distribution (Vd), it is likely that this drug
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The route of drug administration that will give the MOST rapid onset of the pharmacologic effect is
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The bioequivalence of two tablets containing an identical amount of the same drug manufactured by different companies is best determined by measuring
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Thiopentone is of shorter duration of action than phenobarbitone because thiopentone
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Which of the following is NOT administered as a racemic mixture?
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Drugs that demonstrate non-linear pharmacokinetics show which of the following properties?
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It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70 kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was:
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A new cardiac glycoside has been developed for oral and intravenous (IV) administration. The drug has an elimination half-life of 24 hours and an apparent volume of distribution (Vd) of 3 L/kg. The effective drug concentration in plasma is 1.5 ng/mL. Toxic effects of the drug are observed at drug concentrations above 4 ng/mL. The drug is 75% bioavailable after an oral dose. Calculate an oral maintenance dose to be given once a day for a 65 kg male patient (age 68 years) with congestive heart failure and normal renal function. The aim is to achieve an average plasma concentration of 1.5 ng/mL. The dose should be
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Salicylic acid has a pKa of 3.0 and undergoes significant renal tubular reabsorption. In aspirin overdose the renal clearance of salicylic acid will be increased to the greatest extent by
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Which of the following drugs has the longest half-life?
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The most common bacterial genus associated with acne vulgaris is
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Which of the following microbes will NOT be covered by clindamycin?
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The five antibody classes are
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Which of the following statements is FALSE in regards to the use of combination antiinfective therapy?
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Which of the following regimens is appropriate for managing herpes simplex encephalitis?
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All of the following are official pharmacopoeial testing procedures for tablets EXCEPT
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An example of an osmotic laxative is
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A suspension is NOT a suitable dosage form for what type of injection?
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Insulin preparations are usually administered by
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Methylcellulose and similar agents are MOST commonly used in ophthalmic solutions to
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In which base should hydrocortisone acetate be incorporated to give maximal topical absorption?
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The term "impalpable" refers to a substance that is
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Sodium metabisulphite is used as
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 1
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%
FAIL
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%
Pass
Section 2
Data obtained from two different batches of tablets of a new hypoglycaemic agent undergoing clinical trial revealed that Batch 1 contains 200 mg of the drug and has an absolute bioavailability of 55%. Batch 2 contains 200 mg of the drug and relative to the first batch has a bioavailability of 165% What is the absolute bioavailability of the second batch?
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How much ichthammol would be required to be added to a 5% w/w ichthammol in yellow soft paraffin ointment to prepare 200 g of a 17.5% w/w ichthammol in yellow soft paraffin ointment?
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How many grams of chlorbutol are required to make 500 mL of an aqueous solution of such a concentration that 25 mL diluted to 100 mL with water will give a 1:2000 solution?
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Dopamine 200 mg in 500 mL of normal saline at 5 μg/kg/min is ordered for a 70 kg patient. At what rate (mL/min) should the solution be infused to deliver the desired dose of 5 μg/kg/min?
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Lignocaine hydrochloride is available for intravenous injection as a 2% solution packed in 5 mL disposable syringes. The dose is 1 mg per kg of body weight by slow intravenous injection. The volume of solution that should be used for a patient weighing 60 kg is
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A solution with a concentration of 0.0125 % may also be described as containing
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Lugol's Solution contains 5% of iodine, and the usual dose of the solution is 0.3 mL three times a day. The amount of iodine contained in the daily dose of the solution is
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An infusion solution of sodium chloride 0.9% contains a sodium ion concentration of
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A pharmacist has to prepare an aqueous solution containing 1 g of benzalkonium chloride in 2 L, by diluting a 10% solution. How many mL of water will be required?
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The normal daily adult oral dose of celecoxib is within the range
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Which of the following β-adrenergic blockers is predominantly renally cleared?
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Dose levels of vancomycin should be reduced in patients suffering from
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The normal adult daily dose of hydrochlorothiazide is within the range
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For ongoing control of seizures phenytoin may be administered
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Which of the following drugs should NOT be added to the therapy of a poorly controlled diabetic patient already on maximum doses of metformin and glibenclamide?
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Which of the following medicines is NOT safe to use in children under 12 years of age?
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Naloxone
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Sodium Chloride 0.9% is a good wound cleansing agent for the following reasons EXCEPT it
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Which one of the following statements relating to carbamazepine is FALSE?
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Mr Earl, a patient with congestive heart failure, has been taking digoxin 125 mcg/day for one month and has a plasma digoxin concentration of 0.5 mcg/L (The therapeutic range for digoxin in patients with congestive heart failure is 0.5-0.8 mcg/L.) Mr Earl is not showing adequate clinical improvement. The MOST appropriate course of action is to
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Mood disorders are being more widely managed with anticonvulsants. Which of the following is FALSE with regard to anticonvulsants used in this fashion?
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When considering the usefulness of metformin monotherapy for a patient with type 2 diabetes mellitus, relevant patient factors to consider include
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When monitoring anticoagulation with heparin, which of the following does NOT apply?
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The Mantoux test uses
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Which of the following is NOT true of methadone?
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Interferons are indicated in which of the following conditions?
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Which of the following compounds is unlikely to contribute to serotonin syndrome?
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A 75-year-old male, with carcinoma of the prostate with local metastatasis, would be best treated with which of the following?
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Metoclopramide is often given together with oral aspirin for the treatment of acutemigraine attacks. The rationale behind the use of metoclopramide is that it will
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Which of the following drugs has been associated with interstitial pulmonary fibrosis?
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Methysergide, when used for the prophylaxis of migraine
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Cationic exchange resins are most commonly used to treat
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Which of the following procedures should be used to monitor effective enoxaparin doses?
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The following drugs can cause syndrome of inappropriate anti diuretic hormone (SIADH) EXCEPT
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Chronic phenytoin therapy has been associated with
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Which of the following properties is NOT true of indomethacin?
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Which one of the following antipsychotic agents provides the lowest risk of extrapyramidal side effects?
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Which of the following is contraindicated in nursing mothers because it inhibits milk production?
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A 47-year-old premenopausal female with endometriosis is treated with danazol. Which of the following adverse effects is associated with danazol?
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The most prevalent side effect of the chronic use of aluminium hydroxide gel is
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Which of the following is a common sign of digoxin toxicity?
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Sensitisation to sunlight may be produced in a patient being treated with
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A common anticholinergic (atropine-like) side-effect of many drugs is
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The use of pethidine in the management of chronic pain is discouraged because it
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Halothane
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Which of the following has been shown to be teratogenic?
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Moclobemide is useful in Parkinson's disease because it inhibits
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Which of the following has been shown to cause syndrome of inappropriate antidiuretic hormone release (SIADH)?
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Which of the following is associated with lethargy, nightmares and cold extremities as side effects?
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The following medicines have been reported to cause asthma attacks in susceptible people EXCEPT
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Amiodarone may cause all of the following EXCEPT
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The following drugs can cause an increase in the plasma concentration of digoxin with increased risk of toxicity EXCEPT
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Food containing tyramine should NOT be part of the diet of patients taking which of the following antidepressants?
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Theophylline has a very narrow therapeutic index. This drug has severe dose related toxicity (seizures and arrhythmias) which may occur without preceding milder symptoms of toxicity (vomiting and diarrhoea). Theophylline concentrations are raised by a number of commonly used drugs. Three such drugs are
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Which of the following compounds may increase the effects of warfarin?
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Which or the following oral antibiotics should not be taken at the same time as oral iron (Fe2+) containing products?
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If a patient stabilised on digoxin is then administered amiodarone
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The following points should be included in your counselling advice to a person using topical sunscreen agents to prevent sunburn EXCEPT
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The preferred thyroid preparation for maintenance replacement therapy is which of the following drugs?
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Single daily doses of simvastatin are best taken at
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When dispensing a prescription for sucralfate the pharmacist should tell the patient that
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Which of the following anticonvulsants is included in pregnancy Category D?
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A patient with a superficial wound asks what time period is recommended between tetanus immunisations?
Please select 2 correct answers
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Time to peak effect of salmeterol is
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In Parkinson's disease which of the following drugs is contraindicated?
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Which of the following adverse effects could be seen with hydrochlorothiazide?
1
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Each Slow-K dosage unit contains 8 mmoL of potassium as potassium chloride. How many mg of potassium chloride are in each Slow-K tablet? [Atomic Weight K = 39, Cl = 35]
1
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Which of the following agents is MOST similar to hydrochlorothiazide?
1
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When captopril is added to Ms Williams’ regimen, there is an increased likelihood of
1
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Captopril is MOST similar in action to
1
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 2
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%
FAIL
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%
Pass
amzing reat job