Tag: Oral Agents

Brands Classes DEA Class; Rx Common Brand Names; Orinase Antidiabetics, Sulfonylureas Description First-generation oral sulfonylurea; least potent and shortest-acting sulfonylurea; lacks active metabolitesUsed in adults for the treatment of type 2 diabetes mellitus; however, second-generation agents are preferredMay be useful in the elderly or patients with renal disease Indications Indicated for adjunctive treatment of type…

Brands Classes DEA Class; Rx Common Brand Names; Januvia  Antidiabetics, Dipeptyl Peptidase-IV Inhibitors Description Oral DPP-4 inhibitor given once daily; reduces the breakdown of GLP-1 which increases insulin secretionUsed in adults for type 2 diabetes mellitus; mean A1C reduction 0.65 to 1.05%Used as monotherapy or in combination with other hypoglycemic agents including insulin, but not…

Brands Classes DEA Class; Rx Common Brand Names; Onglyza Antidiabetics, Dipeptyl Peptidase-IV Inhibitors Description Oral DPP-4 inhibitor given once daily; reduces breakdown of GLP-1 which increases insulin secretionUsed in adults for type 2 diabetes mellitus; mean A1C reduction 0.4 to 0.9%Used as monotherapy or in combination with other hypoglycemic agents including insulin, but not GLP-1…

Discontinued Classes DEA Class; Rx Common Brand Names; Avandamet Antidiabetics, Biguanides/Thiazolidinediones Description Oral combination of metformin, a biguanide, and rosiglitazone, a thiazolidinedione (TZD)Used in adults for type 2 diabetes mellitus; rosiglitazone is not to be used with insulinRisk of lactic acidosis due to metformin is low; TZDs may cause or exacerbate heart failure; monitor closely…

Brands Classes DEA Class; Rx Common Brand Names; Avandia  Antidiabetics, Thiazolidinediones Description Thiazolidinedione (TZD) oral antidiabetic; targets insulin resistanceUsed in adults with type 2 diabetes mellitus; not used with insulin due to increased risks for heart failureMonitor closely; TZDs can cause or exacerbate heart failure (boxed warning) Indications Indicated as adjunct to diet and exercise…

Brands Classes DEA Class; Rx Common Brand Names; PrandiMet Antidiabetics, Biguanides/Meglitinides Description Combination of a meglitinide oral antidiabetic agent, repaglinide, and the biguanide metforminUsed in adults to treat type 2 diabetes mellitus; most commonly used in patients not achieving goals with either agent aloneBoxed warning regarding lactic acidosis Indications Indicated as adjunct to diet and…

Brands Classes DEA Class; Rx Common Brand Names; Prandin Antidiabetics, Meglitinides Derivatives Description Meglitinide oral hypoglycemic agent; stimulates insulin secretionRapid onset and short duration of action replicates physiological insulin profiles around mealsUsed for the treatment of type 2 diabetes mellitus in adults; not commonly used as monotherapy Indications Indicated as an adjunct to diet and…

Brands Classes DEA Class; Rx Common Brand Names; Oseni Antidiabetics, Dipeptyl Peptidase-IV Inhibitors;  Antidiabetics, Thiazolidinediones Description Oral combination of a thiazolidinedione (pioglitazone) and a dipeptidy-peptidase-4 (DPP-4) inhibitor (alogliptin)Used for the treatment of type 2 diabetes mellitus in adultsDue to the pioglitazone component, monitor patients for edema or signs/symptoms of heart failure Indications Indicated for the…

Brands Classes DEA Class; Rx Common Brand Names; Actos Antidiabetics, Thiazolidinediones Description Thiazolidinedione (TZD) oral antidiabetic; targets insulin resistanceUsed in adults with type 2 diabetes mellitus; use with caution in combination with insulinMonitor closely; TZDs can cause or exacerbate heart failure (boxed warning) Indications Indicated as monotherapy or with insulin or insulin secretagogues For the…

Brands Classes DEA Class; Rx Common Brand Names; Starlix Antidiabetics, Meglitinides Derivatives Description Meglitinide oral hypoglycemic agent; stimulates insulin secretionRapid onset and short duration of action replicates physiological insulin profiles around mealsUsed prior to meals for the treatment of type 2 diabetes mellitus in adults; not commonly used as monotherapy Indications Indicated for the treatment…

Brands Classes DEA Class; Rx Common Brand Names; Glyset Antidiabetics, Alpha-Glucosidase Inhibitors Description Oral alpha-glucosidase inhibitor; in contrast to acarbose, miglitol is systemically absorbed before acting in GI tractUsed for the treatment of type 2 diabetes mellitusAgents in this class have only modest effects on A1C (i.e., mean 0.3% to 0.7% reduction) Indications Indicated for…

Brands Classes DEA Class; Rx Common Brand Names; ACTOplus Met, ACTOplus Met XR  Antidiabetics, Biguanides/Thiazolidinediones Description Oral combination of pioglitazone, a thiazolidinedione (TZD), and metformin, a biguanideUsed in adults for type 2 diabetes mellitus; use with caution with insulinRisk of lactic acidosis due to metformin is low; TZDs may cause or exacerbate heart failure; monitor…

Brands Classes DEA Class; Rx Common Brand Names; Janumet, Janumet XR Antidiabetics, Biguanides/Dipeptyl Peptidase-IV Inhibitors Description Oral combination of metformin with a sodium-glucose co-transporter 2 (SGLT2) inhibitorUsed for adults with type 2 diabetes mellitusContraindicated in severe renal impairment due to reduced canagliflozin efficacy and increased risk of metformin-related lactic acidosis Indications Indicated as an adjunct…

Brands Classes DEA Class; Rx Common Brand Names; Janumet, Janumet XR Antidiabetics, Biguanides/Dipeptyl Peptidase-IV Inhibitors Description Oral combination of a biguanide (metformin) and a dipeptidy-peptidase-4 (DPP-4) inhibitor (sitagliptin)Used in adults for the treatment of type 2 diabetes mellitusPer boxed warning the risk of lactic acidosis due to metformin requires care in prescribing and monitoring Indications…

Brands Classes DEA Class; Rx Common Brand Names; Kombiglyze XR Antidiabetics, Biguanides/Dipeptyl Peptidase-IV Inhibitors Description Oral combination of a biguanide (metformin) and a dipeptidy-peptidase-4 (DPP-4) inhibitor (saxagliptin)Used in adults for the treatment of type 2 diabetes mellitusPer boxed warning the risk of lactic acidosis due to metformin requires care in prescribing and monitoring Indications Indicated…