Tag: Microtubule Inhibitors

Brands Classes DEA Class; Rx Common Brand Names; Navelbine Antineoplastics, Vinca Alkaloid Description Semi-synthetic vinca alkaloid; microtubule inhibitorUsed for the treatment of metastatic non-small cell lung cancerVesicant; closely monitor for signs and symptoms of extravasation Indications Indicated for the treatment of non-small cell lung cancer (NSCLC). Indicated for metastatic non-small cell lung cancer (NSCLC) Indicated…

Brands Classes DEA Class; Rx Common Brand Names; Marqibo Antineoplastics, Vinca Alkaloid Description Liposome-encapsulated formulation of vincristine sulfate, a vinca alkaloid agentUsed for the treatment of adult patients with relapsed Philadelphia chromosome-negative ALLNeurologic toxicity (e.g., peripheral neuropathy and paralytic ileus) and myelosuppression have been reported Indications Indicated for treating Philadelphia chromosome-negative acute lymphoblastic leukemia in…

Brands Classes DEA Class; Rx Common Brand Names; Velban Antineoplastics, Vinca Alkaloid Description A vinca alkaloid agentUsed for acute leukemias in pediatric and adult patients; used as part of combination therapy for Hodgkin lymphoma, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumorFor IV use only; may be fatal if given as an intrathecal injection Indications For…

Brands Classes DEA Class; Rx Common Brand Names; Abraxane Antineoplastics, Antimicrotubular Description Nanoparticle albumin-bound taxane; a microtubule inhibitorUsed for metastatic breast cancer, locally advanced or metastatic NSCLC, and metastatic pancreatic cancerDo not start a new cycle if ANC is less than 1,500 cells/mm3; myelosuppression requires monitoring and possible adjustments in therapy Indications Indicated for metastatic…

Brands Classes DEA Class; Rx Common Brand Names; Velban Antineoplastics, Vinca Alkaloid Description Vinblastine is a member of the Vinca alkaloid antineoplastic agents; extracted from the periwinkle plant; similar to vincristine in action and structure, but the alkaloids significantly differ in toxicities and spectrum of activity; the dose-limiting toxicity of vinblastine is bone-marrow suppression. Indications…

Brands Classes DEA Class; Rx Common Brand Names; Taxol Antineoplastics, Antimicrotubular (Taxanes) Description Semisynthetic, diterpenoid taxane derivative from the bark of the Pacific yew tree; sequence of administration in combination with other agents is important in toxicity and efficacy; effective in numerous disease including breast, lung, ovarian, and bladder cancers, Kaposi’s sarcoma alone or as…

Brands Classes DEA Class; Rx Common Brand Names; Taxotere Antineoplastics, Antimicrotubular (Taxanes) Description A taxane microtubule inhibitorUsed for certain types of breast cancer, non-small cell lung cancer, gastric cancer, prostate cancer, and head and neck cancerOral corticosteroid premedication required prior to each dose to reduce the incidence and severity of hypersensitivity, fluid retention, and skin…