Tag: Class 1 (Na-Channel Blackers)

  • Dextromethorphan/Quinidine

    Brands Classes DEA Class; Rx Common Brand Names; Nuedexta NMDA Antagonists Description Oral combination of dextromethorphan and low-dose quinidine.Used for pseudobulbar affect (PBA); quinidine, a 2D6 inhibitor, increases the bioavailability of dextromethorphan, the active entity.Due to the potential for quinidine to cause QT prolongation, contraindications apply to patients with certain cardiac conditions or those receiving…

  • Quinidine

    Brands Classes DEA Class; Rx Common Brand Names; Quinaglute, Quinidex, quinidine gluconate Antidysrhythmics, Ia;  Antimalarials Description Parenteral and oral class IA antiarrhythmic; used for atrial arrhythmias and ventricular tachycardia; also used for severe malaria. Indications Indicated for conversion to and/or maintenance of sinus rhythm in patients with atrial fibrillation, atrial flutter, or ventricular tachycardia; or for…

  • Propafenone

    Brands Classes DEA Class; Rx Common Brand Names; Rythmol, Rythmol SR Antidysrhythmics, Ic Description Oral class IC antiarrhythmic; used to suppress life-threatening ventricular arrhythmias; mechanism similar to encainide and flecainide; possesses beta-blocking activity; proarrhythmic; should be initiated in the hospital to allow for appropriate ECG monitoring. Indications Indicated for the treatment of sustained ventricular tachycardia…

  • Procainamide

    Brands Classes DEA Class; Rx Common Brand Names; Pronestyl (SR) Antidysrhythmics, Ia Description IV class IA antiarrhythmic agentUsed for atrial fibrillation/flutter, paroxysmal atrial tachycardia, and ventricular tachycardiaDerivative of the local anesthetic procaine Indications Indicated for the treatment of ventricular tachycardia with pulses (stable monomorphic or wide-complex regular ventricular tachycardia) during cardiopulmonary resuscitation (CPR) in patients…

  • Mexiletine

    Brands Classes DEA Class; Rx Common Brand Names; Tambocor Antidysrhythmics, Ib Description Oral, Class IB, local anesthetic-type antiarrhythmic; similar to lidocaine and tocainide; used to treat life-threatening ventricular arrhythmias; associated with proarrhythmic effects; also used successfully to treat neuropathic pain due to diabetic neuropathy. Indications Indicated Oral, Class IB, local anesthetic-type antiarrhythmic; similar to lidocaine…

  • Flecainide

    Brands Classes DEA Class; Rx Common Brand Names; Tambocor Antidysrhythmics, Ic Description Oral Class IC antiarrhythmic; used to treat documented life-threatening ventricular arrhythmias; should be avoided in LVD or asymptomatic post-MI patients; also approved for prevention of PSVT; not considered first-line agent for suppression of ventricular arrhythmias due to risk of proarrhythmias (CAST trial). Indications…

  • Disopyramide

    Brands Classes DEA Class; Rx Common Brand Names; Norpace, Norpace CR Antidysrhythmics, Ia Description Oral class IA antiarrhythmic; similar pharmacology to procainamide and quinidineUsed only for life-threatening ventricular arrhythmiaSignificant proarrhythmic, anticholinergic, and negative inotropic properties limit its use Indications Indicated for the treatment of documented, life-threatening arrhythmias such as sustained ventricular tachycardia.For maintenance of sinus…