Tag: Carbapenems

Brands Classes DEA Class; Rx Common Brand Names; Vabomere Carbapenems Description Combination of meropenem, a carbapenem antibacterial, and vaborbactam, a beta-lactamase inhibitorUsed for complicated urinary tract infections (cUTIs) including pyelonephritis in adults caused by susceptible E. coli, K. pneumoniae, and E. cloacaeActivity against meropenem-resistant organisms, including KPC-producing Enterobacteriaceae Indications Indicated for complicated urinary tract infections…

Brands Classes DEA Class; Rx Common Brand Names; Merrem IV Carbapenems Description IV carbapenem antibioticUsed for complicated intraabdominal and skin and skin structure infections and bacterial meningitisMay have a lower incidence of ADRs than imipenem Indications Indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus…

Brands Classes DEA Class; Rx Common Brand Names; Recarbrio Carbapenems Description Imipenem: Carbapenem; inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins resulting in bacterial cell lysis Cilastatin: Prevents renal metabolism of imipenem by competing with dehydropeptidase in the renal tubules Relebactam: Has no intrinsic antibacterial activity; protects imipenem from degradation by certain serine beta-lactamases…

Brands Classes DEA Class; Rx Common Brand Names; Invanz Carbapenems Description Beta-lactam antibiotic derived from thienamycin. Cilastatin added to reduce renal metabolism of imipenem. Without cilastatin, imipenem is rapidly metabolized and causes toxicity to the proximal tubule. Cilastatin has no antibacterial activity. Imipenem is more efficient at penetrating through the bacterial cell wall, resistant to…

Brands Classes DEA Class; Rx Common Brand Names; Invanz Carbapenems Description IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamasesUsed to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxisOnce-daily dosing may be advantageous, but no P. aeruginosa activity  Indications Indicated for the treatment of Community-Acquired Pneumonia Indicated for the…

Brands Classes DEA Class; Rx Common Brand Names; Doribax Carbapenems Description IV broad spectrum carbapenem antibioticFor complicated intraabdominal and urinary tract infections in adultsSpectrum of activity similar to imipenem and meropenem but is more active in vitro against Pseudomonas aeruginosa Indications Indicated for the treatment of complicated intraabdominal infections. For the treatment of complicated urinary…