Tag: Antimetabolites

Brands Classes DEA Class; Rx Common Brand Names; Folotyn Antineoplastics, Antimetabolite Description Novel antifolate for relapsed or refractory peripheral T-cell lymphoma, a rare form of non-Hodgkin’s lymphoma. Indications Indicated for relapsed or refractory PTCL Contraindications Hypersensitivity Adverse Effects Inflammatory disease of mucous membrane, Any grade (70% ) Thrombocytopenia, Any grade (41% ) Nausea (40% )…

Brands Classes DEA Class; Rx Common Brand Names; Alimta, Pemfexy Antineoplastics, Antimetabolite Description Pyrimidine-based antifolate that targets multiple enzymes, including thymidine synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferaseUsed for the treatment of NSCLC and mesotheliomaRequires supplementation with folic acid and vitamin B12 to mitigate hematologic and GI toxicities, and dexamethasone for cutaneous toxicities Indications Indicated…

Brands Classes DEA Class; Rx Common Brand Names; Trexall, Otrexup, Rasuvo, Xatmep, RediTrex, Jylamvo Antineoplastics, Antimetabolite;  DMARDs, Immunomodulators;  Immunosuppressants Description Folate antimetaboliteUsed for malignant (e.g., breast cancer, non-Hodgkin lymphoma, ALL) and nonmalignant diseases (e.g., rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis); intrathecal methotrexate used for prophylaxis and treatment of meningeal leukemiaUse is contraindicated in patients with a…

Brands Classes DEA Class; Rx Common Brand Names; Purinethol, Purixan, 6Mercaptopurine, 6MP Antineoplastics, Antimetabolite;  Immunomodulators Description Thiopurine antimetaboliteIndicated for ALL as part of a combination chemotherapy regimen; common off-label use in gastroenterology for Crohn’s disease and ulcerative colitisPatients with TPMT or NUDT15 deficiency may be at a higher risk for developing toxicity, especially severe myelosuppression Indications…

Brands Classes DEA Class; Rx Common Brand Names; Gemzar, Infugem Antineoplastics, Antimetabolite Description Deoxycytidine antimetabolite nucleoside inhibitorUsed for breast cancer, non-small cell lung cancer (NSCLC), ovarian cancer, and pancreatic cancerIncreased toxicities occur with infusion times longer than 60 minutes or with dosing more than once weekly Indications Indicated as a single-agent for pancreatic cancer Various…

Brands Classes DEA Class; Rx Common Brand Names; Adrucil, Efudex, Carac, Fluoroplex, Tolak Antineoplastics, Antimetabolite Dermatologics, Other;  Antineoplastics, Topical Description Antimetabolite antineoplastic agent; fluorinated pyrimidine antineoplastic agent; toxicities and efficacy of 5-FU differ depending upon the route of administration; used for breast, colorectal, gastrointestinal, and head and neck cancers; used topically for malignant keratoses. Indications Indicated…

Brands Classes DEA Class; Rx Common Brand Names; Fludara, Oforta Antineoplastics, Antimetabolite Description Purine nucleoside antineoplastic agentUsed for the treatment of adult patients with B-cell chronic lymphocytic leukemia who have not responded to or whose disease has progressed during treatment with at least 1 standard alkylating agent-containing regimenLife-threatening or fatal autoimmune reactions have been reported;…

Brands Classes DEA Class; Rx Common Brand Names; Vyxeos Antineoplastics, Anthracycline;  Antineoplastics, Antimetabolite Description Liposomal combination of daunorubicin (an anthracycline topoisomerase inhibitor) and cytarabine (a nucleoside metabolic inhibitor)Used for newly diagnosed therapy-related AML or AML with myelodysplasia-related changes in adults and pediatric patients aged 1 year and olderSevere bleeding events and hypersensitivity reactions have been…

Brands Classes DEA Class; Rx Common Brand Names; Cytosar U, DepoCyt Antineoplastics, Antimetabolite Description Pyrimidine antimetabolite anitneoplastic agent; used in the treatment of hematologic malignancies; has limited cytotoxicity in solid tumors; a liposomal product is also available  Indications Indicated for the treatment of acute myelogenous leukemia (AML). For the treatment of acute lymphocytic leukemia (ALL).For…

Brands Classes DEA Class; Rx Common Brand Names; Leustatin DSC, Mavenclad Antineoplastics, Antimetabolite Description Parenteral and oral, synthetic purine nucleoside antimetaboliteUsed for various lymphomas and leukemias and relapsing forms of multiple sclerosisAssociated with serious, generally dose-dependent and reversible, bone marrow suppression and increased risk of infection Indications Indicated for the treatment of relapsing forms of…

Brands Classes DEA Class; Rx Common Brand Names; Xeloda Antineoplastics, Antimetabolite Description Antimetabolite antineoplastic agent; oral prodrug of fluorouracilUsed for the treatment of colorectal cancer and breast cancerHas not been associated with alopecia, and myelosuppression is uncommon; hand-foot syndrome is dose-limiting Indications Indicated for the treatment of metastatic breast cancer. For the treatment of colorectal…

Brands Classes DEA Class; Rx Common Brand Names; Vidaza, Onureg Antineoplastics, DNA Methylation Inhibitor Description A pyrimidine nucleoside analog chemotherapy agentUsed IV or subcutaneously in adults with certain myelodysplastic syndrome subtypes; used orally in adults with acute myelogenous leukemiaInjectable formulation contraindicated in patients with advanced malignant hepatic tumors or hypersensitivity to mannitol; oral product should…