Tag: Antihypertensives
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Perindopril/Amlodipine
Brands Classes DEA Class; Rx Common Brand Names; Prestalia ACEI/CCB Combos Description Combination dihydropyridine calcium-channel blocker (amlodipine) and ACE inhibitor (perindopril)Used for hypertensionBlack box warning for use during pregnancy Indications Indicated for the treatment of hypertension in patients likely to need multiple drugs to achieve their blood pressure goals or in patients not adequately controlled…
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Perindopril
Brands Classes DEA Class; Rx Common Brand Names; Aceon ACE Inhibitors Description Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart ACE inhibitors also…
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Quinapril
Brands Classes DEA Class; Rx Common Brand Names; Accupril ACE Inhibitors Description Oral ACE inhibitor; prodrug metabolized to active quinaprilat; used 1-2 times daily for HTN; given twice daily for CHF. Indications Indicated for the treatment of hypertension For the treatment of heart failure.For the treatment of diabetic cardiovascular autonomic neuropathy. Contraindications Hypersensitivity History of…
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Moexipril
Brands Classes DEA Class; Rx Common Brand Names; Univasc ACE Inhibitors Description Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart ACE inhibitors also…
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Lisinopril
Brands Classes DEA Class; Rx Common Brand Names; Prinivil, Zestril, Qbrelis ACE Inhibitors Description Long-acting, oral ACE inhibitorUsed for hypertension, congestive heart failure, post-myocardial infarction, and diabetic nephropathyCan be dosed once daily; slower onset and a longer duration of action than either captopril or enalapril Indications Indicated for the treatment of hypertension For the treatment of…
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Fosinopril
Brands Classes DEA Class; Rx Common Brand Names; Monopril ACE Inhibitors Description Oral ACE inhibitor; prodrug metabolized to active fosinoprilat; used once daily or in divided doses for both HTN and CHF; also has been used post-MI, but not FDA-approved; does not require dosage adjustment in renal failure, hepatic impairment, or dialysis. Indications Indicated for…
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Enalapril
Brands Classes DEA Class; Rx Common Brand Names; enalaprilat, Epaned, Vasotec, Vasotec IV ACE Inhibitors Description IV and oral ACE inhibitor; used for hypertension and CHF; longer-acting than captopril but shorter-acting than other ACE inhibitors; usually dosed twice daily when given orally. Indications Indicated for the treatment of hypertension For the treatment of heart failure.For the…
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Captopril
Brands Classes DEA Class; Rx Common Brand Names; Capoten, Captoril ACE Inhibitors Description Shortest acting, oral ACE inhibitor; contains a sulfhydryl group; side effects increase at higher doses; may be used for HTN, CHF, and various renal syndromes (e.g., diabetic nephropathy, proteinuria, scleroderma renal crisis). Indications Indicated for the treatment of hypertension For the treatment…
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Benazepril/Amlodipine
Brands Classes DEA Class; Rx Common Brand Names; Lotrel Antihypertensive Combos, Other; ACEI/CCB Combos; Calcium Channel Blockers, Dihydropyridine Description Oral combination product containing a dihydropyridine calcium-channel blocker (amlodipine) and an angiotensin-converting enzyme (ACE) inhibitor (benazepril)Used for hypertension in adultsUsed after titration of individual medication components Indications Indicated for the treatment of hypertension in patients who…
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Benazepril
Brands Classes DEA Class; Rx Common Brand Names; Lotensin ACE Inhibitors Description Direct renin inhibitorUsed for hypertensionBlack box warning for pregnancy Indications Indicated ACE inhibitorUsed for hypertension and congestive heart failureLong duration of action allows for once daily dosing Contraindications Hypersensitivity History of hereditary or idiopathic angioedema Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE…
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Aliskiren/Amlodipine
Discontinued Classes DEA Class; Rx Common Brand Names; Tekamlo Renin Inhibitors/Combos; Antianginal Agents; Calcium Channel Blockers, Dihydropyridine; CCB/Renin Inhibitor Combos Description Combination of a direct renin inhibitor and calcium-channel blocker for hypertension. Indications Indicated for the treatment of hypertension, either alone or in combination with other antihypertensive agents. May switch to aliskiren/amlodipine if patient inadequately…
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Aliskiren
Brands Classes DEA Class; Rx Common Brand Names; Tekturna Renin Inhibitors Description Direct renin inhibitorUsed for hypertensionBlack box warning for pregnancy Indications Indicated for treatment of hypertension in adults and children ≥6 years Contraindications Hypersensitivity Coadministration with ARBs or ACE inhibitors in patients with diabetes mellitus Children <2 years Adverse Effects Diarrhea (2.3%) Cough (1.1%)…
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Sacubitril/Valsartan
Brands Classes DEA Class; Rx Common Brand Names; Entresto Angiotensin Receptor-Neprilysin Inhibitors (ARNi); ARBs; Neprilysin Inhibitors Description Oral combination product containing a neprilysin inhibitor (sacubitril) and an angiotensin II receptor blocker (valsartan)Used for heart failure; usually administered in conjunction with other heart failure therapies in place of an ACE inhibitor or other ARB in adult…
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Valsartan
Brands Classes DEA Class; Rx Common Brand Names; Diovan ARBs Description Oral angiotensin II receptor blocker (ARB)Used in adults to treat hypertension, reduce heart failure related hospitalizations in those with heart failure (NYHA Class II to IV), and reduce cardiovascular mortality risk in those with left ventricular failure or dysfunction post-myocardial infarctionAlso used to treat…
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Telmisartan/Amlodipine
Brands Classes DEA Class; Rx Common Brand Names; Twynsta ARB/CCB Combos; Antianginal Agents; Calcium Channel Blockers, Dihydropyridine Description Angiotensin II antagonist (telmisartan) combined with dihydropyridine calcium-channel blocker (amlodipine) for treatment of hypertension. Indications Indicated for treatment of hypertension Contraindications Hypersensitivity Do not coadminister with aliskiren in patients with diabetes mellitus Adverse Effects Peripheral edema (1-11%)…