Tag: Antiemetics

Brands Classes DEA Class; Rx Common Brand Names; Varubi Antiemetic Agents;  NK1 Receptor Antagonists Description Substance P/neurokinin 1 (NK1) receptor antagonistUsed in combination with dexamethasone and a 5-HT3 receptor antagonist for the prevention of CINVContraindicated with CYP2D6 substrates with a narrow therapeutic index, such as thioridazine and pimozide Indications Indicated for delayed chemotherapy-induced nausea/vomiting prophylaxis,…

Brands Classes DEA Class; Rx Common Brand Names; Emend IV NK1 Receptor Antagonists;  Antiemetic Agents Description Selective substance P (NK1) antagonist, fosaprepitant is prodrug of aprepitantUsed for prevention of chemotherapy-induced nausea/vomiting (CINV) due to highly and moderately emetogenic regimens; IV aprepitant (Aponvie) used for prevention of post-operative nausea/voming (PONV)For CINV use with in combination with…

Brands Classes DEA Class; Rx Common Brand Names; Cinvanti, Aponvie, Emend PO Antiemetic Agents;  NK1 Receptor Antagonists Description Selective substance P (NK1) antagonist, fosaprepitant is prodrug of aprepitantUsed for prevention of chemotherapy-induced nausea/vomiting (CINV) due to highly and moderately emetogenic regimens; IV aprepitant (Aponvie) used for prevention of post-operative nausea/voming (PONV)For CINV use with in combination…

Brands Classes DEA Class; Rx Common Brand Names; Inapsine Antiemetic Agents;  Description Parenteral butyrophenone derivative, sedative-hypnotic structurally similar to haloperidol; more potent antiemetic, but less antipsychotic properties compared to haloperidol; due to the risk of QT prolongation and torsade de pointes, limited indication for surgical nausea and vomiting prophylaxis in patients refractory to other treatments.…

Brands Classes DEA Class; Rx Common Brand Names; Reglan, Metozolv ODT Antiemetic Agents;  Prokinetic Agents Description Oral, parenteral, and nasal GI prokinetic agentUsed for diabetic gastroparesis and select adults with GERD; injection helpful for PONV prevention, chemotherapy-induced emesis, and as a procedural adjunctUse should be kept to 12 weeks or less due to risk for…

Brands Classes DEA Class; Rx Common Brand Names; Akynzeo, fosnetupitant Antiemetic Agents;  Antiemetics, Selective 5-HT3 Antagonist;  NK1 Receptor Antagonists Description Combination of a selective substance P neurokinin 1 (NK1) receptor antagonist and highly selective 5-HT3 receptor antagonistUsed with dexamethasone for prevention of CINV due to chemotherapy, including, but not limited to, highly emetogenic chemotherapyPalonosetron prevents…

Brands Classes DEA Class; Rx Common Brand Names; Aloxi Antiemetics, Selective 5-HT3 Antagonist Description Parenteral 5-HT3 receptor antagonistUsed for prevention of post-operative nausea and vomiting and acute and delayed chemotherapy-induced nausea and vomitingLong half-life allows for one-time dosing within a 7-day period for CINV Indications Indicated for prevention of acute N/V associated with moderately or…

Brands Classes DEA Class; Rx Common Brand Names; Zofran, Zofran ODT, Zuplenz Antiemetics, Selective 5-HT3 Antagonist Description Antiemetic; 5-HT3 receptor antagonistUsed for prevention and treatment of nausea and vomiting due to chemotherapy, radiation therapy and surgeryRisk of dose-dependent QT prolongation and torsades de pointes Indications Indicated for chemotherapy-induced nausea/vomiting prophylaxis (CINV prophylaxis) and radiation-induced nausea/vomiting prophylaxis…

Brands Classes DEA Class; Rx Common Brand Names; Sustol, Sancuso, Granisol Oral Solution Antiemetics, Selective 5-HT3 Antagonist Description Oral/intravenous/subcutaneous/transdermal 5-HT3 antagonistUsed to offset nausea/vomiting from moderately or highly emetogenic chemotherapy; also used for prevention of radiation-induced nausea/vomiting, and the immediate-release IV formulation is also approved for postoperative nausea/vomitingRisk of dose-dependent QT prolongation and torsades de pointes…

Brands Classes DEA Class; Rx Common Brand Names; Anzemet Antiemetics, Selective 5-HT3 Antagonist Description Oral/intravenous antiemetic; 5-HT3 receptor antagonistOral tablet used for prevention of chemotherapy-induced nausea/vomiting; injection used for prevention and treatment of PONVRisk of dose-dependent QT prolongation and torsades de pointes Indications Indicated for the treatment of Cancer Chemotherapy Induced Nausea & Vomiting Indicated…