Tag: Anticancer Drugs

Brands Classes DEA Class; Rx Common Brand Names; Trexall, Otrexup, Rasuvo, Xatmep, RediTrex, Jylamvo Antineoplastics, Antimetabolite;  DMARDs, Immunomodulators;  Immunosuppressants Description Folate antimetaboliteUsed for malignant (e.g., breast cancer, non-Hodgkin lymphoma, ALL) and nonmalignant diseases (e.g., rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis); intrathecal methotrexate used for prophylaxis and treatment of meningeal leukemiaUse is contraindicated in patients with a…

Brands Classes DEA Class; Rx Common Brand Names; Purinethol, Purixan, 6Mercaptopurine, 6MP Antineoplastics, Antimetabolite;  Immunomodulators Description Thiopurine antimetaboliteIndicated for ALL as part of a combination chemotherapy regimen; common off-label use in gastroenterology for Crohn’s disease and ulcerative colitisPatients with TPMT or NUDT15 deficiency may be at a higher risk for developing toxicity, especially severe myelosuppression Indications…

Brands Classes DEA Class; Rx Common Brand Names; Gemzar, Infugem Antineoplastics, Antimetabolite Description Deoxycytidine antimetabolite nucleoside inhibitorUsed for breast cancer, non-small cell lung cancer (NSCLC), ovarian cancer, and pancreatic cancerIncreased toxicities occur with infusion times longer than 60 minutes or with dosing more than once weekly Indications Indicated as a single-agent for pancreatic cancer Various…

Brands Classes DEA Class; Rx Common Brand Names; Adrucil, Efudex, Carac, Fluoroplex, Tolak Antineoplastics, Antimetabolite Dermatologics, Other;  Antineoplastics, Topical Description Antimetabolite antineoplastic agent; fluorinated pyrimidine antineoplastic agent; toxicities and efficacy of 5-FU differ depending upon the route of administration; used for breast, colorectal, gastrointestinal, and head and neck cancers; used topically for malignant keratoses. Indications Indicated…

Brands Classes DEA Class; Rx Common Brand Names; Fludara, Oforta Antineoplastics, Antimetabolite Description Purine nucleoside antineoplastic agentUsed for the treatment of adult patients with B-cell chronic lymphocytic leukemia who have not responded to or whose disease has progressed during treatment with at least 1 standard alkylating agent-containing regimenLife-threatening or fatal autoimmune reactions have been reported;…

Brands Classes DEA Class; Rx Common Brand Names; Vyxeos Antineoplastics, Anthracycline;  Antineoplastics, Antimetabolite Description Liposomal combination of daunorubicin (an anthracycline topoisomerase inhibitor) and cytarabine (a nucleoside metabolic inhibitor)Used for newly diagnosed therapy-related AML or AML with myelodysplasia-related changes in adults and pediatric patients aged 1 year and olderSevere bleeding events and hypersensitivity reactions have been…

Brands Classes DEA Class; Rx Common Brand Names; Cytosar U, DepoCyt Antineoplastics, Antimetabolite Description Pyrimidine antimetabolite anitneoplastic agent; used in the treatment of hematologic malignancies; has limited cytotoxicity in solid tumors; a liposomal product is also available  Indications Indicated for the treatment of acute myelogenous leukemia (AML). For the treatment of acute lymphocytic leukemia (ALL).For…

Brands Classes DEA Class; Rx Common Brand Names; Leustatin DSC, Mavenclad Antineoplastics, Antimetabolite Description Parenteral and oral, synthetic purine nucleoside antimetaboliteUsed for various lymphomas and leukemias and relapsing forms of multiple sclerosisAssociated with serious, generally dose-dependent and reversible, bone marrow suppression and increased risk of infection Indications Indicated for the treatment of relapsing forms of…

Brands Classes DEA Class; Rx Common Brand Names; Xeloda Antineoplastics, Antimetabolite Description Antimetabolite antineoplastic agent; oral prodrug of fluorouracilUsed for the treatment of colorectal cancer and breast cancerHas not been associated with alopecia, and myelosuppression is uncommon; hand-foot syndrome is dose-limiting Indications Indicated for the treatment of metastatic breast cancer. For the treatment of colorectal…

Brands Classes DEA Class; Rx Common Brand Names; Vidaza, Onureg Antineoplastics, DNA Methylation Inhibitor Description A pyrimidine nucleoside analog chemotherapy agentUsed IV or subcutaneously in adults with certain myelodysplastic syndrome subtypes; used orally in adults with acute myelogenous leukemiaInjectable formulation contraindicated in patients with advanced malignant hepatic tumors or hypersensitivity to mannitol; oral product should…