Tag: Anticancer Drugs
-
Melphalan
Brands Classes DEA Class; Rx Common Brand Names; Alkeran (DSC), Evomela Antineoplastics, Alkylating Description Alkylating agentUsed in the palliative treatment of unresectable epithelial ovarian cancer (Alkeran tablets), the palliative treatment of multiple myeloma (Alkeran tablets or injection), and as a high-dose conditioning treatment prior to an autologous stem-cell transplant in patients with multiple myeloma (Evomela)Boxed…
-
Lomustine
Brands Classes DEA Class; Rx Common Brand Names; Ifex Antineoplastics, Alkylating Description Nitrosourea alkylating agentUsed for the treatment of Hodgkin lymphoma and brain cancersFatal myelosuppression has been reported; give only 1 lomustine dose at a time with a minimum interval of 6-weeks between doses Indications Indicated for the treatment of Hodgkin lymphoma in patients who…
-
Ifosfamide
Brands Classes DEA Class; Rx Common Brand Names; Ifex Antineoplastics, Alkylating Description Alkylating agent; synthetic analog of cyclophosphamideUsed for the treatment of advanced testicular cancer, along with several off-label usesBlack box warnings for myelosuppression, neurotoxicity, nephrotoxicity, and hemorrhagic cystitis Indications Indicated in combination with other antineoplastic agents for third-line germ cell testicular cancer For the…
-
Dacarbazine
Brands Classes DEA Class; Rx Common Brand Names; DTIC Dome Antineoplastics, Alkylating Description Alkylating antineoplastic agent; used in the treatment of melanoma, sarcoma, and Hodgkin’s disease. Indications Indicated for the treatment of metastatic malignant melanoma. For the treatment of Hodgkin lymphoma.For the treatment of unresectable or metastatic osteogenic sarcoma, in combination with mesna, ifosfamide, and…
-
Chlorambucil
Brands Classes DEA Class; Rx Common Brand Names; Leukeran Antineoplastics, Alkylating Description Oral alkylating agentApproved for use as palliative treatment of chronic lymphocytic leukemia, Hodgkin lymphoma, and certain non-Hodgkin’s lymphomas including lymphosarcoma and giant follicular lymphomaHas black box warnings for severe myelosuppression, carcinogenicity, teratogenicity, and infertility Indications Indicated for the treatment of chronic lymphocytic leukemia…
-
Carmustine
Brands Classes DEA Class; Rx Common Brand Names; BiCNU, Gliadel Antineoplastics, Alkylating Description A nitrosourea alkylating agentIV formulation used for brain tumors including malignant gliomas and glioblastoma multiforme, multiple myeloma, Hodgkin lymphoma, and non-Hodgkin’s lymphoma; implantable wafer used for newly diagnosed high-grade glioma as an adjunct to surgery and radiation and for recurrent glioblastoma as…
-
Busulfan
Brands Classes DEA Class; Rx Common Brand Names; Myleran, Busulfex Antineoplastics, Alkylating; Immunosuppressives, PHD Description A bifunctional alkylating agentIV formulation used in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic stem-cell transplantation in patients with chronic myelogenous leukemia (CML); oral tablet formulation used for palliative treatment of CMLBlack box warning for myelosuppression…
-
Mitoxantrone
Brands Classes DEA Class; Rx Common Brand Names; Novantrone Antineoplastics, Anthracenedione; Multiple Sclerosis Treatments Description Anthracenedione; structurally similar to the anthracyclines; causes less cardiotoxicity than anthracylines; not a vesicant; used in hematologic malignancies and prostate cancer; also effective in relapsing-remitting and secondary progressive MS. Indications Indicated for the treatment of acute myelogenous leukemia (AML). For…
-
Idarubicin
Brands Classes DEA Class; Rx Common Brand Names; Idamycin Antineoplastics, Anthracycline Description Anthracycline chemotherapy agentUsed in combination with other antileukemia drugs in adults with acute myelogenous leukemiaCardiotoxicity and myelosuppression have been reported Indications Indicated for the treatment of acute myelogenous leukemia (AML). For the treatment of acute promyelocytic leukemia (APL).For the treatment of acute lymphocytic…
-
Epirubicin
Brands Classes DEA Class; Rx Common Brand Names; Ellence Antineoplastics, Anthracycline Description Anthracycline topoisomerase inhibitorUsed for node-positive early breast cancerContraindicated in patients with severe drug-induced myelosuppression, severe myocardial insufficiency, recent myocardial infarction, severe arrhythmias, and severe hepatic impairment Indications Indicated as a component of adjuvant therapy in patient with evidence of axillary node tumor involvement…
-
Doxorubicin
Brands Classes DEA Class; Rx Common Brand Names; Adriamycin, Caelyx, Rubex, Doxil, Lipodox, Myocet Antineoplastics, Anthracycline Description A cytotoxic anthracycline antibiotic that inhibits nucleotide replication and repairApproved for use in certain types of leukemias, lymphomas, and solid tumorsCardiotoxicity including congestive heart failure has been reported; use is contraindicated in patients with severe myocardial insufficiency or recent myocardial…
-
Daunorubicin
Brands Classes DEA Class; Rx Common Brand Names; Cerubidine Antineoplastics, Anthracycline Description Anthracycline chemotherapy agentUsed in combination with other anticancer drugs in patients with acute leukemiasCardiotoxicity and myelosuppression have been reported Indications Indicated for the treatment of acute nonlymphocytic leukemia including acute myelogenous leukemia (AML). For the treatment of acute lymphocytic leukemia (ALL). Contraindications Hypersensitivity…
-
Bleomycin
Brands Classes DEA Class; Rx Common Brand Names; Blenoxane Antineoplastics, Antibiotic Description Antibiotic antineoplasticMixture of 13 glycopeptides; active component is the A-2 peptideUsed for Hodgkin lymphoma, NHL, testicular cancer, squamous cell cancer of the head and neck and cervix, and malignant pleural effusions. Indications Indicated for the treatment of Hodgkin lymphoma. For the treatment of…