DrugsAce

Tag: Anticancer Drugs

  • Osimertinib

    Brands Classes DEA Class; Rx Common Brand Names; Tasigna Antineoplastics, Tyrosine Kinase Inhibitor Description An oral EGFR kinase inhibitorUsed for certain types of non-small cell lung cancerSerious adverse effects include QTc prolongation, neutropenia, and ILD/pneumonitis Indications Non-Small Cell Lung Cancer Adjuvant therapy Indicated as adjuvant therapy after tumor resection for non-small cell lung cancer (NSCLC)…

  • Nilotinib

    Brands Classes DEA Class; Rx Common Brand Names; Tasigna Antineoplastics, Tyrosine Kinase Inhibitor Description BCR-ABL tyrosine kinase inhibitorUsed in certain types of Philadelphia chromosome-positive chronic myelogenous leukemiaMay cause QT prolongation; sudden death has been reported Indications Indicated for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Contraindications Long QT syndrome, hypokalemia, hypomagnesemia Adverse…

  • Imatinib

    Brands Classes DEA Class; Rx Common Brand Names; Gleevec Antineoplastics, Tyrosine Kinase Inhibitor;  PDGFR-alpha Inhibitors Description Oral BCR-ABL tyrosine kinase inhibitorUsed in Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia in adults and pediatric patients, and myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia, dermatofibrosarcoma protuberans, and malignant gastrointestinal…

  • Idelalisib

    Brands Classes DEA Class; Rx Common Brand Names; Zydelig Antineoplastics, PI3K Inhibitors Description Phosphatidylinositol 3-kinase inhibitorUsed in adults for the treatment of relapsed chronic lymphocytic leukemia in combination with rituximab and as a single-agent for the treatment of relapsed follicular lymphoma or small lymphocytic lymphoma following at least 2 prior therapiesBlack box warning for fatal…

  • Ibrutinib

    Brands Classes DEA Class; Rx Common Brand Names; Imbruvica Antineoplastics, Tyrosine Kinase Inhibitor Description An oral Bruton’s tyrosine kinase (BTK) inhibitorUsed in adult patients with mantle cell lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma, marginal zone lymphoma, and Waldenstrom macroglobulinemia and in adults and pediatric patients aged 1 year and older with chronic graft-versus-host diseaseSerious…

  • Erlotinib

    Brands Classes DEA Class; Rx Common Brand Names; Tarceva Antineoplastics, Tyrosine Kinase Inhibitor;  Antineoplastics, EGFR Inhibitor Description Oral epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)Used for the treatment of metastatic non-small cell lung cancer (NSCLC) with exon 19 deletions or exon 21 (L858R) substitution mutations as monotherapy, and for the treatment of locally advanced, unresectable,…

  • Dasatinib

    Brands Classes DEA Class; Rx Common Brand Names; Sprycel Antineoplastics, Tyrosine Kinase Inhibitor Description Oral multi-tyrosine kinase inhibitorUsed in adult patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia with resistance or intolerance to prior therapy; also used in pediatric patients with chronic-phase Ph+ CMLSevere myelosuppression has been reported Indications…

  • Dabrafenib

    Brands Classes DEA Class; Rx Common Brand Names; Tafinlar Antineoplastics, BRAF Kinase Inhibitor Description BRAF kinase inhibitor; confirm presence of the BRAF V600 mutation using an FDA-approved testUsed as a single-agent in advanced BRAF V600 mutation-positive melanoma or in combination with trametinib for BRAF V600E mutation-positive solid tumorsMonitor patients who have glucose-6-phosphate dehydrogenase deficiency for…

  • Afatinib

    Brands Classes DEA Class; Rx Common Brand Names; Gilotrif Antineoplastics, Tyrosine Kinase Inhibitor;  Antineoplastics, EGFR Inhibitor Description Oral tyrosine-kinase inhibitorUsed for certain types of metastatic non-small cell lung cancerWithhold afatinib for severe or prolonged diarrhea not responsive to anti-diarrheal agents Indications Non-Small Cell Lung Cancer Metastatic Non-Small Cell Lung Cancer Indicated for first-line treatment in…

  • Trastuzumab/​Hyaluronidase

    Brands Classes DEA Class; Rx Common Brand Names; Herceptin Hylecta, trastuzumab-hyaluronidase-oysk Antineoplastics, Anti-HER2;  Antineoplastics, Monoclonal Antibody   Description Trastuzumab is a HER2/neu receptor antagonist; hyaluronidase is an endoglycosidaseUsed for the treatment of HER2-overexpressing breast cancerDo not substitute trastuzumab; hyaluronidase with other trastuzumab-based products; both administration and dosing recommendations are different Indications Indicated for adjuvant treatment…

  • Trastuzumab

    Brands Classes DEA Class; Rx Common Brand Names; Herceptin, Ogivri, Herzuma, Ontruzant, Trazimera, Kanjinti, trastuzumab-dkst, trastuzumab-pkrb, trastuzumab-dttb, trastuzumab-qyyp, trastuzumab-anns  Antineoplastics, Anti-HER2;  Antineoplastics, Monoclonal Antibody Description Recombinant DNA-derived humanized IgG1 kappa monoclonal antibody against the HER2 proteinUsed for breast and gastric cancers that overexpress HER2Monitor left ventricular ejection fraction in all patients before, during, and after treatment;…

  • Rituximab

    Brands Classes DEA Class; Rx Common Brand Names; Rituxan, Truxima, rituximab-abbs, Ruxience, rituximab-pvvr, rituximab-arrx, Riabni DMARDs, Other;  Antineoplastics, Anti-CD20 Monoclonal Antibodies Description Anti-CD20 monoclonal antibodyUsed for non-Hodgkin lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, microscopic polyangiitis, and pemphigus vulgarisBoxed warnings for severe infusion-related and mucocutaneous reactions, risk of hepatitis B virus reactivation, and progressive…

  • Ramucirumab

    Brands Classes DEA Class; Rx Common Brand Names; Cyramza Antineoplastics, VEGF Inhibitor Description Intravenous human monoclonal antibody that inhibits VEGFR2Used for advanced gastric or gastro-esophageal junction adenocarcinoma, metastatic NSCLC, and hepatocellular cancerSevere infusion reactions have occurred; premedicate all patients with IV diphenhydramine or equivalent; add acetaminophen and dexamethasone (or equivalent) for patients with a previous…

  • Panitumumab

    Brands Classes DEA Class; Rx Common Brand Names; Vectibix Antineoplastics, Monoclonal Antibody;  Antineoplastics, EGFR Inhibitor Description Anti-EGFR monoclonal antibodyUsed for wild-type RAS metastatic colorectal cancer as monotherapy or in combination with chemotherapyDermatologic adverse reactions and severe infusion reactions may occur Indications Indicated for both KRAS and NRAS as determined by an FDA-approved test for this…

  • Daratumumab

    Brands Classes DEA Class; Rx Common Brand Names; Darzalex Antineoplastics, Monoclonal Antibody;  Antineoplastics, Anti-CD38 Monoclonal Antibodies Description Anti-CD38 monoclonal antibodyUsed as monotherapy or in combination with other agents for multiple myelomaType and cross-match patient blood prior to starting treatment Indications Multiple Myeloma Newly diagnosed multiple myeloma Combination therapy with bortezomib, melphalan, and prednisone Indicated in…