Tag: Alkylating Agents

Brands Classes DEA Class; Rx Common Brand Names; Temodar Antineoplastics, Alkylating Description Alkylating antineoplastic agentUsed for the treatment of newly diagnosed glioblastoma multiforme and refractory anaplastic astrocytomaSevere hematologic toxicity and hepatotoxicity have been reported Indications Indicated for the treatment of adults with refractory anaplastic astrocytoma (ie, patients with disease progression on a drug regimen containing…

Brands Classes DEA Class; Rx Common Brand Names; Alkeran (DSC), Evomela Antineoplastics, Alkylating Description Alkylating agentUsed in the palliative treatment of unresectable epithelial ovarian cancer (Alkeran tablets), the palliative treatment of multiple myeloma (Alkeran tablets or injection), and as a high-dose conditioning treatment prior to an autologous stem-cell transplant in patients with multiple myeloma (Evomela)Boxed…

Brands Classes DEA Class; Rx Common Brand Names; Ifex Antineoplastics, Alkylating Description Nitrosourea alkylating agentUsed for the treatment of Hodgkin lymphoma and brain cancersFatal myelosuppression has been reported; give only 1 lomustine dose at a time with a minimum interval of 6-weeks between doses Indications Indicated for the treatment of Hodgkin lymphoma in patients who…

Brands Classes DEA Class; Rx Common Brand Names; Ifex Antineoplastics, Alkylating Description Alkylating agent; synthetic analog of cyclophosphamideUsed for the treatment of advanced testicular cancer, along with several off-label usesBlack box warnings for myelosuppression, neurotoxicity, nephrotoxicity, and hemorrhagic cystitis Indications Indicated in combination with other antineoplastic agents for third-line germ cell testicular cancer For the…

Brands Classes DEA Class; Rx Common Brand Names; DTIC Dome Antineoplastics, Alkylating Description Alkylating antineoplastic agent; used in the treatment of melanoma, sarcoma, and Hodgkin’s disease. Indications Indicated for the treatment of metastatic malignant melanoma. For the treatment of Hodgkin lymphoma.For the treatment of unresectable or metastatic osteogenic sarcoma, in combination with mesna, ifosfamide, and…

Brands Classes DEA Class; Rx Common Brand Names; Leukeran Antineoplastics, Alkylating Description Oral alkylating agentApproved for use as palliative treatment of chronic lymphocytic leukemia, Hodgkin lymphoma, and certain non-Hodgkin’s lymphomas including lymphosarcoma and giant follicular lymphomaHas black box warnings for severe myelosuppression, carcinogenicity, teratogenicity, and infertility Indications Indicated for the treatment of chronic lymphocytic leukemia…

Brands Classes DEA Class; Rx Common Brand Names; BiCNU, Gliadel Antineoplastics, Alkylating Description A nitrosourea alkylating agentIV formulation used for brain tumors including malignant gliomas and glioblastoma multiforme, multiple myeloma, Hodgkin lymphoma, and non-Hodgkin’s lymphoma; implantable wafer used for newly diagnosed high-grade glioma as an adjunct to surgery and radiation and for recurrent glioblastoma as…

Brands Classes DEA Class; Rx Common Brand Names; Myleran, Busulfex Antineoplastics, Alkylating;  Immunosuppressives, PHD Description A bifunctional alkylating agentIV formulation used in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic stem-cell transplantation in patients with chronic myelogenous leukemia (CML); oral tablet formulation used for palliative treatment of CMLBlack box warning for myelosuppression…