Tag: 2nd Generation Antipsychotics
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Ziprasidone
Brands Classes DEA Class; Rx Common Brand Names; Geodon Antipsychotics, 2nd Generation; Antimanic Agents Description Oral and parenteral atypical antipsychotic; belongs to benzisoxazole/benzoisothiazol derivatives classUsed orally in adults for schizophrenia, as monotherapy for acute episodes of bipolar I disorder, and as an adjunct to lithium or valproate for maintenance treatment of bipolar I disorder; IM…
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Risperidone
Brands Classes DEA Class; Rx Common Brand Names; Risperdal, Risperdal Consta, Risperdal M-Tab, Perseris Antipsychotics, 2nd Generation; Antimanic Agents Description Oral and parenteral atypical antipsychotic of the benzisoxazole classUsed orally and as an extended-release (ER) intramuscular injection in adults for schizophrenia and bipolar I disorder; a subcutaneous ER injection is used for schizophrenia in adults; in…
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Quetiapine
Brands Classes DEA Class; Rx Common Brand Names; Seroquel, Seroquel XR Antipsychotics, 2nd Generation; Antimanic Agents Description Atypical antipsychotic; structurally similar to clozapine; low risk of EPS and hyperprolactinemiaUsed in adults for the treatment of schizophrenia, mania associated with bipolar I disorder, bipolar depression, maintenance of bipolar I disorder, and as an adjunct to antidepressants…
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Pimavanserin
Brands Classes DEA Class; Rx Common Brand Names; Nuplazid Antipsychotics, 2nd Generation; Description Atypical antipsychotic with serotonin modulator activityUsed for hallucinations and delusions associated with Parkinson’s disease psychosis; not approved for patients with dementia-related behavioral problems unrelated to Parkinson’s disease psychosisMay cause QT prolongation; avoid use with other drugs that prolong the QT interval and…
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Paliperidone
Brands Classes DEA Class; Rx Common Brand Names; Invega, Invega Sustenna, Invega Trinza, Invega Hafyera Antipsychotics, 2nd Generation; Description Atypical antipsychotic that is the active metabolite of risperidoneOral product used for schizophrenia / schizoaffective disorder in adults and schizophrenia in adolescents 12 years and older; the monthly (Invega Sustenna), 3-month (Invega Trinza), and 6-month (Invega Hafyera)…
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Olanzapine/Samidorphan
Brands Classes DEA Class; Rx Common Brand Names; Lybalvi Antipsychotics, 2nd Generation; Serotonin-Dopamine Activity Modulators (SDAM); Antimanic Agents Description Olanzapine: May act through combination of dopamine and serotonin type 2 receptor site antagonism Samidorphan: Opioid antagonist; mitigates weight gain associated with olanzapine Indications Indicated for treatment of schizophrenia in adults For the acute treatment of…
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Fluoxetine/Olanzapine
Brands Classes DEA Class; Rx Common Brand Names; Symbyax Psychotherapeutic Combos Description Atypical antipsychotic and SSRI combinationUsed for treatment-resistant depression in adults, and also for depressive episodes of bipolar I disorder in adults and pediatric patients 10 years and olderBoxed warning related to an increased risk of suicidality in children, adolescents, and young adults, as…
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Olanzapine
Brands Classes DEA Class; Rx Common Brand Names; Zyprexa, Zyprexa Relprevv, Zyprexa Zydis Antipsychotics, 2nd Generation; Antimanic Agents Description Atypical antipsychotic; similar in structure to clozapine, but reduced incidence of EPS, hyperprolactinemia, neutropeniaUsed for the treatment of schizophrenia and for manic or mixed episodes of bipolar I disorder (as monotherapy or in combination with lithium or…
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Lurasidone
Brands Classes DEA Class; Rx Common Brand Names; Latuda Antipsychotics, 2nd Generation; Description Oral atypical antipsychotic; belongs to benzisoxazole/benzoisothiazol derivative classUsed for schizophrenia in adults and adolescents and for bipolar I depression in adult and pediatric patients 10 years and olderContraindicated with strong CYP3A4 inhibitors or inducers; as with all antipsychotics, boxed warning for increased…
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Iloperidone
Brands Classes DEA Class; Rx Common Brand Names; Fanapt Antipsychotics, 2nd Generation; Description Oral atypical antipsychotic; belongs to benzisoxazole/benzoisothiazol derivatives classUsed for the treatment of schizophrenia in adultsAssociated with QT prolongation; as with all antipsychotics, boxed warning for increased mortality risk in elderly patients with dementia-related psychosis Indications Indicated for the treatment of refractory schizophrenia…
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Clozapine
Brands Classes DEA Class; Rx Common Brand Names; Clozaril, Versacloz Antipsychotics, 2nd Generation; Description Oral dibenzodiazepine-type atypical antipsychotic; relatively low potential for extrapyramidal symptomsReserved for adults with refractory schizophrenia and for reducing the risk of suicidal behavior in schizophrenia or schizoaffective disorderClozapine REMS Program ensures proper monitoring, especially for severe neutropenia; boxed warning for increased…
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Cariprazine
Brands Classes DEA Class; Rx Common Brand Names; Vraylar Antipsychotics, 2nd Generation; Bipolar Disorder Agents Description Oral atypical antipsychotic; prolonged monitoring needed due to long half-lives of parent drug and active metaboliteUsed in adults for the treatment of schizophrenia, bipolar depression, and manic or mixed episodes associated with bipolar disorderAs with all antipsychotics, boxed warning…
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Brexpiprazole
Brands Classes DEA Class; Rx Common Brand Names; Rexulti Serotonin-Dopamine Activity Modulators (SDAM) Description Oral atypical antipsychotic of dopamine system stabilizers subclassUsed as adjunctive treatment for adults with major depressive disorder (MDD) or as monotherapy for schizophrenia in adolescents (13 to 17 years old) and adults; review clinically significant drug interactionsBoxed warning related to an…
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Asenapine
Brands Classes DEA Class; Rx Common Brand Names; Saphris, Secuado Antipsychotcs, 2nd Generation; Description Atypical antipsychotic; sublingual and transdermal formsSublingual tablet is used for the treatment of schizophrenia in adults, manic or mixed episodes and maintenance treatment of bipolar I disorder in adults, and for acute mania in pediatric patients 10 years and older; transdermal…
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Aripiprazole
Brands Classes DEA Class; Rx Common Brand Names; Abilify, Abilify Maintena, Abilify MyCite, Aristada, Aristada Initio Antipsychotcs, 2nd Generation; Antimanic Agents Description Oral and parenteral atypical antipsychotic of the dopamine system stabilizers classUsed orally in adults for schizophrenia, bipolar I disorder, and as an adjunct for major depression; short-acting injection used for agitation; distinct extended-release IM…