Orphenadrine/Aspirin/Caffeine

DEA Class; Rx

Common Brand Names; Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte

Analgesics, Other Combos

Oral combination of salicylate analgesic (aspirin), CNS stimulant (caffeine), and centrally acting muscle relaxant (orphenadrine)

Used for acute pain of musculoskeletal disorders

Orphenadrine has anticholinergic properties and is contraindicated in glaucoma and certain GI and urinary diseases

Indicated for symptomatic relief of mild-to-moderate pain caused by acute musculoskeletal disorders as an adjunct to rest, physical therapy, and other measures

Glaucoma

Pyloric or duodenal obstruction

Achalasia

Prostatic hypertrophy or bladder neck obstructions

Myasthenia gravis

Hypersensitivity to orphenadrine, aspirin, or caffeine

Tachycardia

Palpitation

Urinary hesitancy or retention

Dry mouth

Blurred vision

Dilated pupils

Increased intraocular tension

Weakness

Nausea

Vomiting

Headache

Dizziness

Constipation

Drowsiness

Urticaria (rare)

Other dermatosis (rare)

Confusion in elderly individuals (infrequent)

Mild central excitation and occasional hallucinations

Not recommended for use in patients with chicken pox, influenza, or flu symptoms; Reye syndrome may develop in individuals who have chicken pox, influenza, or flu symptoms; studies suggest association between Reye syndrome and use of medicines containing salicylate or aspirin

May impair patient’s ability to engage in potentially hazardous activities (eg, operating machinery, driving a motor vehicle)

Pregnancy; Use of NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment

Lactation; Safety during lactation has not been established

Adults

3080 mg/day PO aspirin, 240 mg/day PO caffeine, and 200 mg/day PO orphenadrine.

Geriatric

3080 mg/day PO aspirin, 240 mg/day PO caffeine, and 200 mg/day PO orphenadrine.

Adolescents

Safety and efficacy have not been established.

Children

Safety and efficacy have not been established.

orphenadrine/aspirin/caffeine

Tablet

50mg/770mg/60mg