Methyltestosterone

DEA Class; Rx

Common Brand Names; Android, Methitest, Testred

Synthetic androgen given orally without loss of bioavailability; has less hepatic metabolism following oral administration when compared to testosterone; has been used in the management of congenital or acquired hypogonadism; pathological, delayed puberty; and as palliative treatment for breast cancer in postmenopausal women. -schedule C-III controlled substance.

Known or suspected prostate CA, males w/ breast cancer

Pregnancy

• Edema
• Acne
• Breast soreness
• Priapism
• Menstrual irregularities
• Virilization
• Edema wiith or without congestive heart failure
• Gynecomastia
• Suppression of clotting factors II, V, VII & X, Erythrocytosis
• Cholestatic jaundice syndrome
• Neoplasm of liver
• Anaphylaxis

Cardiac dz, hepatic dz, renal dz, elderly

Hypercalcemia may occur in breast CA pts

Risk of jaundice, cholestatic hepatitis, abnl LFTs & potentially fatal hepatic peliosis – discontinue if any of these occur

Pts. easily sexually aroused

Pregnancy Category: X

Lactation: excreted into breast milk, avoid

The maximum dosage is dependent on indication for therapy.

The maximum dosage is dependent on indication for therapy.

The maximum dosage is dependent on indication for therapy.

Safety and efficacy have not been established.