Classes
DEA Class; OTC
Common Brand Names; Maginex, Maginex DS
- Electrolytes
Description
Cofactor for many enzymatic pathways involved in phosphate transfer reactions that use ATP and other nucleotides as substrates (eg, oxidative phosphorylation, oxygen radical reduction); involved in enzymatic reactions responsible for carbohydrate metabolism and protein synthesis
May play a role in reducing serum cholesterol and sodium/potassium ATPase responsible for neuromuscular functioning
Indications
Indicated as a Dietary Supplement
Contraindications
Hypersensitivity
Adverse Effects
Diarrhea
Cramps
Gas formation
Warnings
Hypermagnesemia may result with renal impairment
May aggravate existing heart disease
Caution in patients with myasthenia gravis or other neuromuscular disease
Accumulation of magnesium in renal impairment may lead to magnesium intoxication
Magnesium toxicity characterized by flushing, diaphoresis, hypotension, depressed deep tendon reflexes, muscle paralysis, weakness, hypothermia, circulatory collapse, and cardiac, CNS, or respiratory depression
Pregnancy and Lactation
Hypermagnesemia may result with renal impairment
May aggravate existing heart disease
Caution in patients with myasthenia gravis or other neuromuscular disease
Accumulation of magnesium in renal impairment may lead to magnesium intoxication
Magnesium toxicity characterized by flushing, diaphoresis, hypotension, depressed deep tendon reflexes, muscle paralysis, weakness, hypothermia, circulatory collapse, and cardiac, CNS, or respiratory depression
Maximum Dosage
Magnesium Supplementation
19-30 years
Elemental magnesium
Males: 400mg/day
Females: 310mg/day
Pregnant females: 350mg/day
Lactation: 310mg/day
>30 years
Elemental magnesium
Males: 420mg/day
Females: 320mg/day
Pregnant females: 360mg/day
Lactation: 320mg/day
OTC Supplement
Salt form
1 packet (dissolved in water or juice) or 2 tablets (1230 mg) up to 3 times daily
Pediatric
Magnesium Supplementation
Dietary reference intake for elemental magnesium varies in children according to age
<6 months: 30 mg/day
6-12 months: 75 mg/day
1-3 years: 80 mg/day
3-8 years: 130 mg/day
8-13 years: 240 mg/day
Adolescent boys 13-18 years: 410 mg/day
Adolescent girls
13-18 years: 360 mg/day
Pregnant: 400 mg/day
Lactating: 360 mg/day
How supplied
Magnesium gluconate
tablet, enteric-coated
61mg elemental Mg (615mg salt form)
granules for oral solution
122mg elemental Mg/packet (1230mg salt form)