Levorphanol

DEA Class; Rx

Common Brand Names; Levo Dromoran

Opioid agonist
Used for pain severe enough to require opioid analgesic and when other treatments are inadequate
Possible alternative for patients who fail methadone or adverse effects limit use

Absolute: acute abdominal condition, pseudomembranous colitis, respiratory depression

Relative: asthma (acute), inflammatory bowel disease, respiratory impairment

Dizziness

Hypoventilation

Nausea

Pruritus

Hypotension

Constipation

Vomiting

Disturbance of consciousness

Disturbance in mood

Bradyarrhythmia

Cardiac arrest

Cardiac dysrhythmia

Palpitations

Tachyarrhythmia

Apnea

Cardiac arrhythmias, drug abuse/dependence, emotional lability, gallbladder disease, head injury, hepatic impairment, hypothyroidism, increased intracranial pressure, prostatic hypertrophy, renal impairment, seizures with epilepsy, urethral stricture, urinary tract surgery, toxin-mediated diarrhea

Pregnancy Category: B; D if used for prolonged periods or near term

Lactation: not known if excreted in breast milk