Hydrocortisone/Neomycin/Polymyxin Otic

DEA Class; Rx

Common Brand Names; Cortisporin Otic

Indicated for the treatment of superficial bacterial infections of the external auditory canal (i.e., otitis externa) caused by susceptible organisms, and for the treatment of infections of mastoidectomy and fenestration caused by susceptible organisms.

Hypersensitivity to any agent

Cutaneous viral infection of the external auditory canal (solution only); patients with herpes simplex, vaccinia, and varicella infections

Hypersensitivity

Itching

Redness

Skin rash

Swelling

Neomycin sensitization, including itching, reddening, edema, and failure to heal may occur; discontinue therapy if it occurs

Solution does not penetrate quite as well as suspension does

Systemic absorption of topical corticosteroids may cause hypothalamic-pituitary-adrenal axis suppression, which may lead to adrenal crisis, especially in children and in patients receiving large doses for prolonged periods

Prolonged use of corticosteroids may increase the incidence of secondary infection, mask acute infection, and may also prolong or exacerbate viral infections

Development of Kaposi sarcoma associated with prolonged treatment with corticosteroids; discontinue therapy if it occurs

Neomycin can induce permanent sensorineural hearing loss due to cochlear damage, including destruction of hair cells in the organ of Corti; risk of ototoxicity is greater with prolonged use

Percutaneous absorption of topical corticosteroids may occur, which may cause manifestations of hyperglycemia, Cushing syndrome, or glycosuria; use of occlusive dressings, application fo denuded skin, or application to large surface areas may increase risk of absorption

Pregnancy category: C

Lactation: Unknown whether drug is excreted in milk; use with caution