Hydrocortisone/​Iodoquinol

DEA Class; Rx

Common Brand Names; Alcortin, Vytone

Indicated for the treatment of contact dermatitis, atopic dermatitis, impetiginized eczema/ impetigo, nummular eczema, endogenous chronic infectious dermatitis, stasis dermatitis, pyoderma, nuchal eczema, chronic eczematoid otitis externa, acne urticata, localized or disseminated neurodermatitis, lichen simplex chronicus, anogenital pruritus (vulvus, scrotum, anus), folliculitis, bacterial dermatoses (declatoses), mycotic dermatoses (tinea capitis, tinea cruris, tinea corporis, tinea pedis), moniliasis, and intertrigo.

Hypersensitivity

Hepatic insufficienty

Hydrocortisone

• Skin atrophy

• Striae

• Acneform lesions

• Pigmentation changes

• HPA suppression (with higher potency used >2 wk)

• Intracranial hypertension

• Allergic contact dermatitis

• Pruritus

• Pustulation

• Perioral dermatitis

• Urticaria

• Hypertrichosis

• Leukoderma

• Pigmentation changes

Iodoquinol

• Fever

• Vertigo

• Chills

• Headache

• Skin eruptions

• Urticaria

• Rash

• Chills

• Thyroid gland enlargement

• Anal itching

• Diarrhea

• Nausea/vomiting

• Peripheral neuropathy

• Optic neuritis

• Optic atrophy

Chronic topical corticosteroid therapy may interfere with growth and development in children

Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity

External use only

Use on extensive surface area or with occlusive dressing may increase systemic absorption and possibly toxicity

Kaposi’s sarcoma reported with prolonged corticosteroid therapy

Children may exhibit greater susceptibility to corticosteroid-induced HPA axis suppression and Cushing’s syndrome due to larger skin surface area to body weight ratio

Peripheral neuropathy may occur with prolonged use of high doses

Optic neuritis may occur with prolonged use of high doses; avoid long term therapy

Peripharal neuropathy may occur with prolonged use of high doses; avoid long term therapy

Use caution in patients with thyroid disease

Pregnancy Category: C

Lactation: not known whether either drug applied topically enters breast milk; use caution