Ethionamide

DEA Class; Rx

Common Brand Names; Trecator

• Antitubercular Agents

Hypersensitivity to ethionamide

Severe hepatic dysfunction

• Disorder of gastrointestinal tract (50%)
• Postural hypotension
• Depression
• Dizziness
• Drowsiness
• Headache
• Peripheral neuropathy
• Psychosis
• Photosensitivity
• Rash
• Excessive salivation
• Gynecomastia
• Hypoglycemia
• Impotence
• Anorexia
• Dyspepsia
• Diarrhea
• Nausea
• Metallic taste
• Vomiting
• Thrombocytopenia
• Elevated liver transaminases

Use caution in diabetes mellitus, thyroid disease, hepatic impairment

HIV patients may have malabsorption syndrome

Used as monotherapy in the treatment of tuberculosis results in rapid development of resistance; give suitable companion drug or drugs; base the choice on results of susceptibility testing; therapy may be initiated prior to receiving results of susceptibility tests as deemed appropriate by physician; administer with at least one, sometimes two, other drugs to which organism is known to be susceptible

Prescribing drug in the absence of a proven or strongly suspected bacterial infection indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria

Ethionamide may potentiate adverse effects of other antituberculous drugs administered concomitantly

Perform ophthalmologic examinations (including ophthalmoscopy) before and periodically during therapy

Excessive ethanol ingestion should be avoided; psychotic reaction reported

Pregnancy Category: C

Lactation: enters breast milk; safe

Ethionamide

tablet

• 250mg