Classes
DEA Class; Rx
Common Brand Names; Pamelor, Aventyl
- Antidepressants, TCAs
Description
Neurotransmitter (especially NE and serotonin) reuptake inhibitor; increases concentration of neurotransmitte in the central nervous system.
Indications
Depression
Contraindications
Hypersensitivity
Severe cardiovascular disorder
Narrow angle glaucoma
Within 14 days of MAOIs (risk of serotonin syndrome); if linezolid or IV methylene blue (MAOIs) must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity; may resume 24 hr after last linezolid or methylene blue dose, or after 2 weeks of monitoring, whichever comes first
Any drugs or conditions that prolong QT interval
Acute recovery post-MI
Adverse Effects
- Sedation
- Fatigue
- Headache
- Agitation
- Insomnia
- Blurred vision
- Weakness
- Lethargy
- Anxiety
- Dry mouth
- Constipation
- Nausea
- Vomiting
- Sweating
- Weight change
- Confusion
- EPS
- Dizziness
- Tinnitus
- Paresthesia
- Seizure (rare)
- Worsening depression/suicide (rare)
- Orthostatic hypotension
- ECG changes
- Tachycardia
- Paralytic ileus (rare)
- Agranulocytosis (rare)
- Thrombocytopenia (rare)
- Eosinophilia (rare)
- Leukopenia (rare)
- Increased LFTs
- Sexual dysfunction
- Rash
- SIADH (rare)
Warnings
Caution in BPH, urinary/GI retention, hyperthyroidism, open-angle glaucoma, seizure disorder, brain tumor, respiratory impairment
Clinical worsening and suicide ideation may occur despite medication
Risk of anticholinergic side-effects
Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy
Pregnancy and Lactation
Pregnancy Category: C
Lactation: avoid
How supplied
Protriptyline Hcl