Penicillin V

DEA Class; Rx

Common Brand Names; Pen Vee K, Penicillin V, Veetids

Indicated for Streptococcal Pharyngitis

Indicated for Actinomycosis, Erysipelas, Periodontal Infections, Recurrent Rheumatic Fever

Also indicated for Prosthetic Joint Infection (Off-label)

Allergy to penicillins, cephalosporins, or imipenem

Caution in severe renal impairment

Prolonged use may result in superinfection

Use with caution in patients with asthma history; IGE mediated anaphylactic reactions (eg, urticaria, anaphylaxis) reported

Use with caution in neonates; some dosage forms may contain sodium benzoate/benzoic acid, which may cause fatal toxicity (gasping syndrome) when used in large amounts

Adverse effects, including hemolytic anemia, serum sickness, or neutropenia, may occur with prolonged use; serum concentrations may increase with extended duration of therapy, especially in patients with renal insufficiency

Use caution in patients with history of seizure disorders; high serum levels, especially in the presence of renal impairment, may increase risk of seizures

Pregnancy

Penicillin crosses the placenta; use during pregnancy generally has not resulted in an increased risk of fetal adverse effects

Lactation

Penicillin is excreted into breast milk; compatible with breastfeeding