Penicillin G Benzathine

Penicillin G Benzathine
Brands

DEA Class; Rx

Common Brand Names; Bicillin LA, Permapen

  • Penicillins, Natural

Repository form of penicillin for intramuscular use only; tissue depot allows slow drug absorption over several days; provides lower and prolonged serum concentrations compared to aqueous penicillin G; used in mild to moderate infections due to susceptible organisms, prophylaxis and treatment of rheumatic fever, syphilis.

Indicated for Group A Streptococcal Respiratory Infections

For the treatment of upper respiratory tract infections, including group A beta-hemolytic streptococcal (GAS) pharyngitis (primary rheumatic fever prophylaxis) and tonsillitis.
Indicated for Rheumatic Fever Prophylaxis, Syphilis.
For diphtheria carriage eradication.
 

Hypersensitivity; serious and occasionally fatal reactions have been reported

Skin rashes including maculopapular eruptions and exfoliative dermatitis

Urticaria

Serum-sicknesslike reactions (eg, chills, fever, edema, arthralgia, prostration)

Jarisch-Herxheimer reaction reported when treating syphilis

Pseudomembranous colitis

For deep IM administration only; do not administer IV, SC, or IT

Do not inject near nerve or artery

Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) reported in patients taking beta-lactam antibiotics; discontinue therapy when SCAR suspected; consider an alternative treatment

Pseudomembranous colitis reported with antibacterial agents, including penicillin G

Administer by deep intramuscular injection only in the upper, outer quadrant of buttock (dorsogluteal) or ventrogluteal site; quadriceps femoris fibrosis and atrophy reported following repeated intramuscular injections of penicillin preparations into anterolateral thigh and is not recommended

Pregnancy Category: B

Lactation: Excreted into breast milk, caution advised

Adults

2.4 million units/day IM.

Geriatric

2.4 million units/day IM.

Adolescents

50,000 units/kg/day IM (Max: 2.4 million units/day).

Children

50,000 units/kg/day IM (Max: 2.4 million units/day).

Infants

50,000 units/kg/day IM (Max: 600,0000 units/day).

Neonates

50,000 units/kg/day IM.

Penicillin G benzathine

injectable suspension

  • 600,000 units/1mL
  • 1.2 million units/2mL
  • 2.4 million units/4mL
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