Classes
DEA Class; Rx
Common Brand Names; Ludiomil
- Antidepressants, TCAs
Description
Tetracyclic antidepressant of dibenzo-bicyclo-octadiene derivation; efficacy is similar to the TCAs for depression; occasionally administered for other indications.
Indications
Indicated for the treatment of major depression.
Contraindications
Hypersensitivity
Severe cardiovascular disorders
Narrow angle glaucoma
Within 14 days of MAO inhibitors may cause serotonin syndrome
Any drugs or conditions that prolong QT interval
Acute recovery post-MI
Adverse Effects
Common
Fatigue
Sedation
Lethargy
Weakness
Constipation
Dry mouth
Blurred vision
Less Common
Agitation
Anxiety
Headache
Insomnia
Nausea
Vomiting
Sweating
Infrequent
Orthostatic hypotension, ECG changes, tachycardia
Confusion, EPS, dizziness, paresthesia, tinnitus
Rash
Incr LFTs
Sexual dysfunction
Rare
Seizure
Agranulocytosis
Thrombocytopenia
Eosinophilia
Leukopenia
SIADH
Warnings
Caution in BPH, urinary/GI retention, increased IOP, hyperthyroidism, open-angle glaucoma, seizure disorder, brain tumor, respiratory impairment
Clinical worsening & suicide ideation may occur despite medication in adolescents & young adults (18-24 years)
Risk of anticholinergic side-effects
May cause sedation (may impair physical and mental abilities), orthostatic hypotension, and anticholinergic effects
Pregnancy and Lactation
Pregnancy Category: B
Lactation: avoid during breastfeeding
Maximum Dosage
225 mg/day PO.
225 mg/day PO.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Maprotiline hydrochloride
tablet
- 25mg
- 50mg
- 75mg