Felodipine

DEA Class; Rx

Common Brand Names; Cabren, Cardioplen XL, Felendil XL, Felogen XL, Felotens XL, Keloc SR, Neofel XL, Plendil, Renedil, Vascalpha

• Calcium Channel Blockers; 
• Calcium Channel Blockers, Dihydropyridine

Indicated for the treatment of hypertension.

Hypersensitivity

Headache (11-15%)

Peripheral edema (2-17%)

Flushing (4-7%)

Dizziness (1.1-3.4%)

Tachycardia (0.4-2.5%)

Gingival hyperplasia

Rash

Upper respiratory infection

Avoid taking with grapefruit juice

Sustained-release product

May occasionally precipitate significant hypotension and, rarely, syncope; may lead to reflex tachycardia which in susceptible individuals may precipitate angina pectoris

Avoid use in patients with heart failure; lack of benefit or worse outcomes reported with calcium channel blockers in this patient group

Patients with impaired liver function may have elevated plasma concentrations of felodipine and may respond to lower doses; therefore, a lower starting dose recommended; patients should have their blood pressure monitored closely during dosage adjustment

Peripheral edema, generally mild and not associated with generalized fluid retention, is most common adverse effect; incidence is both dose and age-dependent; adverse effect generally occurs within 2–3 weeks of initiation of treatment

Reflex tachycardia may occur resulting in angina and/or MI in patients with obstructive myocardial infarction in patients with obstructive coronary disease in absence of concurrent beta-blockade

Use caution in aortic stenosis; may reduce coronary perfusion resulting in ischemia

Use caution in patients with outflow tract obstruction and hypertrophic cardiomyopathy; reduction in afterload may worsen symptoms of this condition

Pregnancy Category: C

Lactation: excretion in milk unknown/not recommended