Ethacrynic Acid

5
Ethacrynic Acid
Brands

DEA Class; Rx

Common Brand Names; Edecrin

  • Diuretics, Loop

Potent parenteral and oral loop diuretic; useful in patients who are unresponsive to other diuretics; greater risk of ototoxicity when compared to other loop diuretics.

Indicated for the treatment of peripheral edema, including idiopathic edema, lymphedema, or edema secondary to ascites, heart failure, or nephrotic syndrome.

For the treatment of acute pulmonary edema.

For the acute treatment of hypercalcemia associated with neoplastic disease in combination with intravenous saline.

For the treatment of hypertension.

Hypersensitivity to ethacrynic acid

Anuria, severe, watery diarrhea

Use in infants

  • Injection site reaction
  • Hyperuricemia
  • Gout
  • Hypotension
  • Hypokalemia
  • Electrolyte abnormalities
  • Hyperglycemia/hypoglycemia
  • Hyperlipidemia
  • Ototoxicity
  • Tinnitus
  • Photosensitivity
  • Muscle cramps
  • Dizziness
  • Confusion
  • Headache
  • Nausea/vomiting
  • Anorexia
  • Dysphagia
  • Diarrhea
  • Pancreatitis
  • Agranulocytosis
  • Neutropenia
  • Thrombocytopenia
  • Hematuria

Avoid concurrent use with lithium or furosemide

Diabetes mellitus, geriatrics, liver disease, renal impairment

Risk of fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, hypotension, metabolic alkalosis

Risk of ototoxicity (tinnitus, reversible/irreversible hearing impairment)

Discontinue use if severe, watery diarrhea occurs

Pregnancy Category: B

Lactation: excretion in milk unknown/not recommended

Adults

400 mg/day PO or 100 mg/dose IV.

Geriatric

400 mg/day PO or 100 mg/dose IV.

Adolescents

3 mg/kg/day PO; safety and efficacy of IV administration has not been established but 1 mg/kg/dose IV has been used.

Children

3 mg/kg/day PO; safety and efficacy of IV administration has not been established but 1 mg/kg/dose IV has been used.

Infants

Use is contraindicated.

Ethacrynate sodium; Ethacrynic acid

powder for injection

  • 50mg

tablet

  • 25mg
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