Dicloxacillin

3
Dicloxacillin
Generic Only

DEA Class; Rx

Common Brand Names; Dynapen

  • Penicillins, Penicillinase-Resistant

Oral semisynthetic isoxazolyl antistaphylococcal penicillin. Most active of the isoxazolyl antistaphylococcal penicillins. Stable against penicillinase and active against many of the penicillinase-producing strains of Staphylococcus aureus. Clinical uses include skin and soft-tissue, bone and joint, respiratory tract, and urinary tract infections.

Indicated for Staphylococcus aureus infections

Indicated for the treatment of mastitis.

For the treatment of skin and skin structure infections, including impetigo, cellulitis, erysipelas, animal bite wounds, and diabetic foot ulcer.
For the treatment of peritoneal dialysis catheter-related infection.

Hypersensitivity to penicillins, cephalosporins, imipenem

Initial treatment of severe infections

Concomitant live bacterial vaccines

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Anemia
  • Elevated LFTs
  • Fever
  • Hypersensitivity
  • Nephritis
  • Pseudomembranous colitis
  • Seizures with extremely high doses &/or renal failure
  • Rash (maculopapular to exfoliative)
  • Vomiting
  • Vaginitis

Monitor PT if patient is taking warfarin concurrently

Prolonged use may result in superinfection

Elimination of drug in neonates is slow; use caution

Pregnancy Category: B

Lactation: excreted in breast milk, use caution

Adults

1 g/day PO per FDA-approved labeling; however, doses up to 2 g/day PO have been used off-label.

Geriatric

1 g/day PO per FDA-approved labeling; however, doses up to 2 g/day PO have been used off-label.

Adolescents

25 mg/kg/day PO (Max: 1 g/day) per FDA-approved labeling; however, doses up to 50 mg/kg/day PO (Max: 2 g/day) have been used off-label.

Children

25 mg/kg/day PO (Max: 1 g/day) per FDA-approved labeling; however, doses up to 50 mg/kg/day PO (Max: 2 g/day) have been used off-label.

Dicloxacillin

capsule

  • 250mg (generic)
  • 500mg (generic)
DrugsAce
Logo