Cefprozil

DEA Class; Rx

Common Brand Names; Cefzil

Indicated for the treatment of mild to moderate pharyngitis or tonsillitis.

Documented hypersensitivity

• Nausea (3.5%)
• Diarrhea (2.9%)
• Elevated LFTs (2%)
• Diaper rash (1.5%)
• Abdominal pain (1%)
• Dizziness (1%)
• Vomiting (1%)
• eosinophilia
• superinfection
• vaginitis
• Eosinophilia
• Superinfection
• Vaginitis
• Cholestatic jaundice
• Elevated BUN & creatinine
• Prolonged PT

Oral suspension contains aspartame; not indicated for patients with phenylketonuria

Careful inquiry should be made to determine if patient has had previous hypersensitivity to cephalosporins, penicillins or similar drugs; cross sensitivity reported among beta-lactam antibiotics; discontinue therapy if reaction occurs

Hypersensitivity reactions may require treatment with epinephrine and emergency measures, including intravenous fluids, oxygen, corticosteroids, intravenous antihistamines, pressor amines, and airway management as indicated

Prescribing antibiotics in the absence of proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria

Prolonged use of therapy may result in overgrowth of nonsusceptible organisms; careful observation of patient essential; if superinfection occurs during therapy, appropriate measures should be taken

Cefprozil should be prescribed with caution in individuals with a history of gastrointestinal disease particularly colitis

Positive direct Coombs’ tests have been reported during treatment with cephalosporin antibiotics.

Pregnancy Category: B

Lactation: low distribution into breast milk; use with caution