Azilsartan

DEA Class; Rx

Common Brand Names; Edarbi

• ARBs

Angiotensin II receptor antagonist
Used for hypertension
Black box warning for use during pregnancy

Indicated for hypertension, either alone or in combination with other antihypertensives

Hypersensitivity

Do not coadminister with aliskiren in patients with diabetes

• Diarrhea (2%)
• Nausea
• Asthenia
• Fatigue
• Muscle spasm
• Dizziness
• Postural hypotension
• Cough
• Nausea
• Muscle spasm
• Rash, pruritus, angioedema

Abnormally high serum creatinine values more likely reported in patients aged 75 or older

Caution with hyperkalemia

NSAIDs may attenuate antihypertensive response

Coadministration with NSAIDs increase risk of renal impairment including acute renal failure

Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)

Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death

Lactation: unknown whether distributed in breast milk, decide on alternate antihypertensive therapy or do not breastfeed