Classes
DEA Class; Rx
Common Brand Names; Asendin
- Antidepressants, TCAs
Description
Norepinephrine reuptake inhibitor with dopamine antagonist properties
Used for the treatment of major depression in adults, including depression with psychotic features, concurrent anxiety, or agitation
Requires close monitoring in pediatrics and young adults due to increased risk of suicidality during the initial stages of treatment
Indications
Indicated for the treatment of major depression.
Contraindications
Hypersensitivity
Severe cardiovascular d/o
Uncorrected narrow angle glaucoma
Within 14 day of MAOIs (risk of serotonin syndrome); if linezolid or IV methylene blue (MAOIs) must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity; may resume 24 hr after last linezolid or methylene blue dose, or after 2 weeks of monitoring, whichever comes first
Any drugs or conditions that prolong QT interval
Acute recovery post-MI
Adverse Effects
- Constipation (12-14%)
- Dry mouth (12-14%)
- Sedation (12-14%)
- Anxiety
- Ataxia
- Blurred vision
- Confusion
- Dizziness
- Edema
- Headache
- Fatigue
- Nausea
- Nervousness/restlessness
- Prolactin levels increased
- Rash
- Sweating
- Tremor
- Weakness
- Agranulocytosis
- Diarrhea
- ECG changes
- EPS
- Flatulence
- Galactorrhea
- Hypertension
- Leukopenia
- Menstrual irregularity
- Mydriasis
- Orthostatic hypotension
- Seizure
- Urinary retention
- Urticaria
- Vomiting
- Tachycardia
Warnings
BPH, urinary/GI retention, incr IOP, hyperthyroidism, opne angle glaucoma, seizure d/o, brain tumor, respiratory impairment, hyperthyroidism
Clinical worsening & suicide ideation may occur despite medication in adolescents & young adults (18-24 yo)
Risk of anticholinergic side effects
Possibility of tardive dyskinesia & NMS
Pregnancy and Lactation
Pregnancy Category: C
Lactation: enters breast milk; use with caution
Maximum Dosage
400 mg/day PO outpatients; 600 mg/day PO inpatients.
300 mg/day PO, but lower doses (i.e., 150 mg/day PO) often adequate.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Not indicated.
How supplied
Amoxapine
tablet
- 25mg
- 50mg
- 100mg
- 150mg