Classes
DEA Class; Rx
Common Brand Names; Limbitrol, Limbitrol DS
- Antidepressants, TCAs;
- Anxiolytics, Benzodiazepines;
- Psychotherapeutic Combos
Description
Oral antidepressant/anti-anxiety combination product.
Amitriptyline is a tricyclic antidepressant (TCA), chlordiazepoxide is a benzodiazepine.
Common ADRs include anticholinergic effects and drowsiness.
Indications
Indicated for the treatment of moderate to severe depression with concurrent symptoms of moderate to severe anxiety in adult patients.
Contraindications
Hypersensitivity
Severe cardiovascular disorders
Angle clossure glaucoma
Within 14 days of MAOIs
Any drugs or conditions that prolong QT interval
Acute recovery post-MI
Adverse Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
- Bloating
- Vivid dreams
- Impotence
- Tremor
- Confusion
- Nasal congestion
- Edema
- Syncope
- Ataxia
- EEG abnormalities
- Menstrual irregularities
- Blood dyscrasias (agranulocytosis)
- Hepatic dysfunction (jaundice)
Warnings
Caution in BPH, urinary/GI retention, increased IOP, thyroid dysfunction, open-angle glaucoma, seizure disorders, brain tumor, respiratory impairment, respiratory disease,
Clinical worsening & suicide ideation may occur despite medication in adolescents & young adults (aged 18-24 yr)
Write prescription for smallest effective dose
Risk of anticholinergic side-effects
May cause orthostatic hypotension
Paradoxical reactions including hyperactive or aggressive behavior reported
Both agents may cause sedation and impair ability to perform tasks requiring mental alertness
SIADH and hyponatremia reported with therapy
Some patients may experience a large increase in amitriptyline concentration in presence of topiramate; any adjustments in amitriptyline dose should be made according to patient’s clinical response and not on basis of plasma level
Pregnancy and Lactation
Pregnancy Category: D
Lactation: Excretion in milk unknown; not recommended
Maximum Dosage
60 mg/day PO chlordiazepoxide and 150 mg/day PO amitriptyline.
60 mg/day PO chlordiazepoxide and 150 mg/day PO amitriptyline; however, lower total daily doses are usually recommended in the elderly versus younger adults.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Amitriptyline hydrochloride/Chlordiazepoxide
tablet: Schedule IV
- 5mg/12.5mg
- 10mg/25mg