Classes
DEA Class; Rx
Common Brand Names;
- Psychotherapeutic Combos
Description
Oral combination phenothiazine antipsychotic and tricyclic antidepressant
Used for schizophrenia and for moderate to severe anxiety/agitation and associated depressive symptoms
Boxed warning for increased risk of suicidality in children, adolescents, and young adults during early treatment phase and increased mortality risk in elderly patients with dementia-related psychosis
Indications
Indicated for the treatment of depression in patients with moderate to severe anxiety and/or agitation.
Contraindications
Tricyclic Antidepressant (amitriptyline): hypersensitivity, severe cardiovascular disorder, narrow angle glaucoma, within 14 days of MAOIs (risk of serotonin syndrome), any drugs or conditions that prolong QT interval, acute recovery post-MI
Antipsychotic (perphenazine): hypersensitivity, CNS depression, neuroleptic malignant syndrome, poorly controlled seizure disorder, subcortical braine damage, coma, severe obtundation, high dose CNS depressants, blood dyscrasia, myelosuppression, liver damage
Adverse Effects
Myocardial infarction
Heart failure
Stroke
Ventricular tachycardia
Seizures
Coma
Retinopathy
Visual impairment
Laryngeal edema
Warnings
—
Pregnancy and Lactation
Pregnancy Category: D
Lactation: excreted in breast milk; not recommended
Maximum Dosage
The usual maximum is 16 mg/day PO perphenazine and 200 mg/day PO amitriptyline.
16 mg/day PO perphenazine and 200 mg/day PO amitriptyline.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Amitriptyline hydrochloride/perphenazine
tablet
- 10mg/2mg
- 25mg/2mg
- 10mg/4mg
- 25mg/4mg
- 50mg/4mg