Paracetamol/Ibuprofen

DEA Class; OTC

Common Brand Names; Advil Dual Action

Analgesic other Combos

Acetaminophen

Acts on hypothalamus to produce antipyresis

May work peripherally to block pain impulse generation; may also inhibit prostaglandin synthesis in CNS

Ibuprofen

Elicits anti-inflammatory, analgesic, and antipyretic activity

Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2

May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to its anti-inflammatory activity

Indicated for temporary relief of mild pain caused by headache, backache, muscular aches, toothache, menstrual cramps, minor pain of arthritis

Ibuprofen

• Hypersensitivity to ibuprofen, other NSAIDs, aspirin, or excipients
• Perioperative pain in setting of CABG surgery

Acetaminophen

• Hypersensitivity
• Severe active liver disease

GI upset

Hepatotoxicity risk, Allergic reaction, NSAID allergy, GI bleeding

Ibuprofen

There are no adequate and well-controlled studies in pregnant women; data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive

Acetaminophen

Low risk of cryptorchidism in boys if used for several weeks or longer

Lactation

Ibuprofen

No lactation studies have been conducted; however, limited published literature reports that, following oral administration, ibuprofen is present in human milk at relative infant doses of 0.06-0.6% of the maternal weight-adjusted daily dose; no information is available on effects of ibuprofen on milk production or on a breastfed infant

Acetaminophen

Considered compatible with breastfeeding (LactMed)

Acetaminophen containing products: Not to exceed a cumulative dose of 3.25 g/day of acetaminophen; under supervision of healthcare professional, daily doses of up to 4 g/day may be used

Pediatric

Acetaminophen containing products: Not to exceed a cumulative dose of 3.25 g/day of acetaminophen; under supervision of healthcare professional, daily doses of up to 4 g/day may be used

acetaminophen/ibuprofen