Classes
DEA Class; OTC
Common Brand Names; Children’s Triaminic Cough & Sore Throat Daytime, Children’s Tylenol Plus Cough & Sore Throat, Tylenol Cough & Sore Throat Daytime
- Cough/Cold, Non-narcotic Combos
Description
Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.
Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.
Indications
Indicated in Relief of Cold & Flu Symptoms
Contraindications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; dextromethorphan may slow the breathing
Warnings
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Pregnancy and Lactation
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Maximum Dosage
Adults
30mL [(1000mg/30mg)/30mL] PO q6hr; not to exceed 120 mL/day
Pediatric
4 Years Old
Not recommended
4-6 Years Old
5mL [(160mg/5mg)/5mL] PO q4hr; not to exceed 5 doses/day
6-12 Years Old
10mL [(160mg/5mg)/5mL] PO q4hr; not to exceed 5 doses/day
>12 Years Old
30mL [(1000mg/30mg)/30mL] PO q6hr; not to exceed 120mL/day
How supplied
acetaminophen/dextromethorphan
liquid
- (1000mg/30mg)/30mL
- (160mg/5mg)/5mL