Entacapone

DEA Class;  Rx

Common Brand Names; Comtan

Consult your pharmacist or physician.

Use only in combo with levodopa/carbidopa

Not for coadministration with a non-selective MAO inhibitor; monoamine oxidase and catechol-0-methyltransferase (COMT) are both involved in the metabolism of catecholamines as the combination of this drug and a non-selective MAO inhibitor (eg, phenelzine and tranylcypromine) could inhibit the majority of the pathways responsible for normal catecholamine metabolism; however, it may be taken with a selective MAO-B inhibitor, including selegiline

Dopaminergic therapy in Parkinson’s disease patients has been associated with orthostatic hypotension; the drug enhances levodopa bioavailability and, therefore, might be expected to increase occurrence of orthostatic hypotension; syncope reported more frequently in patients with documented hypotension

This drug may potentiate dopaminergic side effects of levodopa and may cause or exacerbate preexisting dyskinesia; although decreasing the dose of levodopa may ameliorate this side effect, many patients in controlled studies continued to experience frequent dyskinesia despite a reduction in their dose of levodopa

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

1,600 mg/day PO. Limited data are available for doses more than 1,600 mg/day.

1,600 mg/day PO. Limited data are available for doses more than 1,600 mg/day.

Safety and efficacy have not been established.

Safety and efficacy have not been established.

Not indicated.