Classes
DEA Class; Rx
Common Brand Names; Tri-Luma
- Corticosteroids, Topical;
- Depigmenting Agents
Description
Hydroquinone: Inhibits melanocyte metabolic processes that produce melanin; incr excretion of melanin from melanocytes
Fluocinolone: Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes
Tretinoin: Follicular epithelium irritant
Indications
Indicated for short-term treatment of moderate to severe melasma
Contraindications
Hypersensitivity
Adverse Effects
- Erythema (41-45%)
- Desquamation (36-40%)
- Burning (16-20%)
- Dryness (11-15%)
- Pruritis (11-15%)
- Acne (5%)
- Telangiectasia (3%)
- Hyperesthesia (2%)
- Rosacea (1%)
- Vesicles (1%)
- Xerostomia (1%)
- Paresthesia (3%)
Warnings
Not indicated for maintenance treatment of melasma
Avoid sun exposure
Safety & efficacy of Tri-Luma in patients of skin types V and VI not studied. Excessive bleaching in pts with darker skin cannot be excluded.
Safety & efficacy in treatment of hyperpigmentation conditions other than melasma of face not studied
Contains sodium matabisulfite which may cause allergic-type reactions in susceptible pts.
Hydroquinone may produce exogenous ochronosis (darkening of skin)- promptly discontinue if occurs
Pregnancy and Lactation
Pregnancy Category: C
Lactation: not known whether excreted in breast milk; use caution
Maximum Dosage
Apply to face qHS, at least 30 min before bedtime
Wash face gently before application; rinse & pat dry
Apply thin film of Tri-Luma to hyperpigmented area & 1/2 inch surrounding skin
Do not use occlusive dressing
How supplied
Fluocinolone/tretinoin/hydroquinone
cream
- (0.01%/0.05%/4%)/30g