Classes
DEA Class; Rx
Common Brand Names; Aldoril
- Thiazide Combos
Description
Hydrochlorothiazide, a thiazide diuretic, and methyldopa, a central antiadrenergic agent, are combined in 1 tablet to treat hypertension; not indicated for initial treatment of hypertension.
Indications
Indicated for the treatment of hypertension.
Contraindications
Anuria
Renal decompensation
Hypersensitivity to either component or sulfonamides
Mitral valve rheumatic heart disease
Active liver disease, such as acute hepatitis and active cirrhosis
Liver disorders previously associated with methyldopa therapy
Concomitant therapy with monoamine oxidase (MAO) inhibitors
Adverse Effects
Methyldopa
Angina
Arthralgia
Bradycardia
Orthostatic hypotension
Depression
Dizziness
Lethargy
Sedation
Rash, liver toxicity
Gynecomastia
Impotence
Dry mouth
Nausea/vomiting
Hemolytic anemia
Thrombocytopenia, lupus-like syndrome
Hydrochlorothiazide
Anorexia
Epigastric distress
Hypotension
Orthostatic hypotension
Photosensitivity
Anaphylaxis
Anemia
Confusion
Erythema multiforme
Stevens-Johnson syndrome
Exfoliative dermatitis including toxic epidermal necrolysis
Hypomagnesemia
Dizziness
Headache
Hyperuricemia
Warnings
This fixed-combination drug is not indicated for initial therapy of hypertension; requires therapy titrated to the individual patient before fixed-combination drug therapy initiated
DM, fluid or electrolyte imbalance, hyperuricemia or gout, liver disease, renal disease, SLE, hypotension
May aggravate digitalis toxicity
Sensitivity reactions may occur with or w/o history of allergy or asthma
Risk of male sexual dysfunction
CHF, dialysis pts (increased risk of hypertension following procedure), edema, hemolytic anemia, severe bilateral CVD
Avoid abrupt withdrawal
Risk of decreased libido and impotence in men
May impair ability to perform hazardous tasks
Tolerance develops on prolonged therapy, especially if no concurrent diuretic (methyldopa causes Na and water retention)
Acute transient myopia and acute angle-closure glaucoma has been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide)
Interferes with some lab tests
Pregnancy and Lactation
Pregnancy Category: C
Lactation: both components appear in breast milk, use caution
Maximum Dosage
NOTE: Additional methyldopa doses may be necessary. Do not exceed maximum dosage for each individual drug.
50 mg/day PO hydrochlorothiazide and 750 mg/day PO methyldopa.
50 mg/day PO hydrochlorothiazide and 750 mg/day PO methyldopa.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Methyldopa/Hydrochlorothiazide
tablet
- 10mg/12.5mg
- 20mg/12.5mg