Pentazocine/Naloxone

Pentazocine/Naloxone

DEA Class; Rx

Common Brand Names; Talwin NX

  • Analgesics, Opioid Combos; 
  • Analgesics, Opioid Partial Agonist

Synthetic opiate agonist-antagonist analgesic combined with a semisynthetic opiate-receptor antagonist
Formulation is intended to prevent pentazocine misuse and abuse
One-sixth to one-third as potent as morphine

Indicated for the treatment of moderate pain to severe pain for which alternative treatments are inadequate.

Hypersensitivity

Do not inject dissolved tablets

If prescribed for long-term use, take precautions to avoid increases in dose by the patient

increased intracranial pressure 
seizures 
toxic epidermal necrolysis 
anaphylactic shock 
angioedema 
Stevens-Johnson syndrome 
erythema multiforme 
neonatal opioid withdrawal syndrome 
serotonin syndrome 
SIADH 

Pregnancy Category: C

Lactation: use caution

Adults

600 mg/6 mg per day PO.

Geriatric

600 mg/6 mg per day PO.

Adolescents

600 mg/6 mg per day PO.

Children

12 years: 600 mg/6 mg per day PO.
1 to 11 years: Safety and efficacy have not been established.

Infants

Safety and efficacy have not been established.

Neonates

Safety and efficacy have not been established.

Pentazocine/naloxone

tablet: Schedule IV

  • 50mg/0.5mg
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