Felbamate

1
Felbamate
Brands

DEA Class;  Rx

Common Brand Names; Felbatol

  • Anticonvulsants, Other

Oral anticonvulsant agent chemically similar to meprobamate, but does not possess muscle-relaxant activity. Used for partial seizures in adults and Lennox-Gastaut syndrome in children and adults. Aplastic anemia and acute hepatic failure limit use to seizures refractory to other agents; close monitoring for emerging or worsening suicidal thoughts/behavior or depression is recommended.

Indicated for the treatment of partial seizures with or without generalization in adults.

For the treatment of partial and generalized seizures associated with Lennox-Gastaut syndrome in children.

Hypersensitivity to carbamates; history of blood dyscrasia, hepatic impairment

Adjunctive therapy

  • Nausea (34.2%)
  • Vomiting (16.7%)
  • Constipation (11.4%)
  • Dyspepsia (12.3%)
  • Anorexia (19.3%)
  • Dyspepsia (12.3%)

Lennox-Gastaut

  • Anorexia (55%)
  • Somnolence (48%)
  • URI (46-50%)
  • Vomiting (39%)
  • Nervousness (16-20%)
  • Insomnia (16.1%)
  • Purpura (11-15%)
  • Fever (22.6%)
  • Constipation (12.9%)

Monotherapy

  • Acne (3.4%)
  • Anxiety (5.2%)
  • Constipation (6.9%)
  • Diarrhea (5.2%)
  • Diplopia (3.4%)
  • Dyspepsia (8.6%)
  • Face edema (3.4%)
  • Fatigue (6.9%)
  • Headache (6.9%)
  • Insomnia (8.6%)
  • Intramenstrual bleeding (3.4%)
  • Otitis media (3.4%)
  • Rash (3.4%)
  • Urinary tract infection (3.4%)
  • Vomiting (8.6%)

Increased risk of suicidal behavior reported with anticonvulsant use; monitor patients for changes in behavior that might indicate suicidal behavior

Associated with increased incidence of aplastic anemia and acute hepatic failure , use only when alternative therapy is unsuitable and benefits outweigh risks

Use caution in renal impairment

Not for use as first line therapy in epilepsy; for use when benefits outweigh risks

Do not discontinue therapy abruptly

Pregnancy Category: C

Lactation: Excreted in milk; not recommended

Adults

3600 mg/day PO.

Elderly

3600 mg/day PO.

Adolescents

3600 mg/day PO.

Children

>= 2 years: 3600 mg/day PO.
< 2 years: Safety and efficacy have not been established.

Felbamate

tablets

  • 400 mg
  • 600 mg

oral suspension

  • 600 mg/5 mL
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