Ziprasidone

DEA Class;  Rx

Common Brand Names; Geodon

Documented hypersensitivity

Any drugs or conditions that prolong QT interval

Recent acute myocardial infarction

Uncompensated heart failure

• Somnolence (11-15%)
• Headache (11%)
• Nausea (4-12%)
• Extrapyramidal symptoms (2-31%)
• Dizziness (3-16%)
• Respiratory disorders (1-8%)
• Constipation (2-9%)
• Dyspepsia (1-8%)
• Rash (4-5%)
• Tachycardia (2%)
• Hypoesthesia (2%)
• Priapism (1%)
• Orthostatic hypotension (5%)
• Xerostomia (1-5%)
• Anorexia (2%)
• Myalgia (2%)
• Rhinitis (1-4%)
• Cough (3%)
• Syncope
• Seizures

Seizure disorders; may cause hypotension, EPS, somnolence, and sensory instability, which could lead to falls and, consequently, fractures or other injuries; for patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy

Atypical antipsychotics have been associated with metabolic changes (eg, hyperglycemia, dyslipidemia, and body weight gain) that may increase cardiovascular/cerebrovascular risk

Hyperglycemia may occur and in some cases may be extreme, resulting in ketoacidosis, hyperosmolar coma, or death; monitor blood glucose of high-risk patients

Neuroleptic malignant syndrome reported with antipsychotic drugs

Tardive dyskinesia, acute dystonic reactions, pseudoparkinsonism, or akathisia may develop acutely or chronically

Discontinue if rash develops without an identified cause

Drug reaction with eosinophilia and systemic symptoms (DRESS) reported; DRESS consists of combination of three or more of the following: cutaneous reaction (such as rash or exfoliative dermatitis), eosinophilia, fever, lymphadenopathy and one or more systemic complications such as hepatitis, nephritis, pneumonitis, myocarditis, and pericarditis; DRESS is sometimes fatal; discontinue therapy if DRESS suspected

There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics.

Limited data from a published case report indicate the presence of drug in human milk