Iloperidone

DEA Class;  Rx

Common Brand Names; Fanapt

Hypersensitivity; anaphylaxis, angioedema, and other hypersensitivity reactions reported

• Dizziness (20%)
• Dry mouth (15%)
• Nausea (10%)
• Somnolence (10%)
• Tachycardia (12%)
• Diarrhea
• Ejaculation failure
• Myalgia
• Nasal congestion
• Orthostatic hypotension
• Palpitations
• Urinary incontinence
• Weight gain
• Amenorrhea
• Edema
• Hypothyroidism
• Priapism
• Retrograde ejaculation
• Hypersensitivity reactions (including anaphylaxis; angioedema; throat tightness; oropharyngeal swelling; swelling of the face, lips, mouth, and tongue; urticaria; rash; and pruritus)

Prolongs QT interval; caution with other drugs/conditions that increase QTc

Not recommended in hepatic impairment

Risk of neuroleptic malignant syndrome and extrapyramidal symptoms

May cause anticholinergic side effects (eg., confusion, agitation)

Blood dyscrasias (leukopenia, neutropenia, agranulocytosis) may occur

Orthostatic hypotension may occur

Cases of priapism reported

Should be avoided in patients with a known genetic susceptibility to congenital long QT syndrome and with a history of cardiac arrhythmias

May cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries; for patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy

Use caution in patients with history of seizures or with conditions that lower seizure threshold

Monitor closely patients at high risk of committing suicide

Hyperprolactinemia may occur; gynecomastia and galactorrhea reported

Antipsychotic agents may disrupt body temperature regulation and may cause esophageal dysmotility and aspiration; use caution

Pregnancy Category: C

Neonates exposed to antipsychotic drugs during the 3rd trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery

These complications vary in severity; in some cases, symptoms have been self-limited, while in other cases neonates have required intensive care unit support and prolonged hospitalization

Lactation: not known if excreted in breast milk, do not nurse