Classes
DEA Class; OTC
Common Brand Names; Allerest Allergy and Sinus Relief, Children’s Tylenol Cold Daytime, Genatap Sinus Maximum Strength, Mapap Sinus Maximum Strength, Medi-Synal, Omex, Oranyl Plus, Sinus-Relief, Tylenol Cold Daytime, Tylenol Sinus Daytime
- Cough/Cold, Other Combos;
- Analgesic/Decongestant Combos
Description
Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.
Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.
Indications
Indicated for Relief of Cold & Flu Symptoms
Contraindications
Documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; known G-6-PD deficiency
Adverse Effects
Arrhythmia
Palpitations
Convulsion
Dizziness
Drowsiness
Excitability
Tremor
Dermatologic rash
Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia)
Bilirubin and alkaline phosphatase may increase
Weakness
Warnings
Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Pregnancy and Lactation
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Maximum Dosage
2 caplets [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours
2 caplets [(500mg/30mg)/caplet] PO q6hr; not to exceed 8 caplets/24hours
Pediatric
<6 Years Old
Ask a pediatrician
6-12 Years Old
1 caplet [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours
>12 Years Old
2 caplets [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours
2 caplets [(500mg/30mg)/caplet] PO q6hr; not to exceed 8 caplets/24hours