Classes
DEA Class; OTC
Common Brand Names; Coricidin HBP Cold & Flu, St. Joseph Cold & Flu
Cough/Cold, Non-narcotic Combos;
Antihistamines, Alkylamine Derivatives
Description
Oral combination of an analgesic/antipyretic and antihistamine
Used for the treatment of fever, headache, minor aches and pains, rhinorrhea, and sneezing
May cause sedation; excitability may occur, especially in children
Indications
Contraindications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Adverse Effects
Hypotension
Palpitations
Tachycardia
Anxiety
Confusion
Depression
Dizziness
Drowsiness
Euphoria
Fatigue
Headache
Insomnia
Irritability
Nervousness
Tremors
Anorexia
Constipation
Diarrhea
Nausea
Vomiting
Agranulocytosis
Anemia
Blood dyscrasias (neutropenia, pancytopenia, leukopenia, thrombocytopenia)
Hemolytic anemia
Bilirubin and alkaline phosphatase may increase
Thickening of bronchial secretions
Wheezing
Dry mouth, nose, throat
Warnings
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Pregnancy and Lactation
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Maximum Dosage
3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.
3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.
3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.
12 years: 3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.
6 to 11 years: 1,625 mg/day PO acetaminophen; 10 mg/day PO chlorpheniramine.
1 to 5 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
acetaminophen/chlorpheniramine
tablet
- 325mg/2mg